Amine-modified single-walled carbon nanotubes protect neurons from injury in a rat stroke model.
Amine-modified single-walled carbon nanotubes protect neurons from injury in a rat stroke model.
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DOI：
10.1038/nnano.2010.281
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发表时间：
2011-02
影响因子：
38.3
通讯作者：
中科院分区：
文献类型：
--
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中风会导致组织结构破坏，是美国第三大死亡原因。已提出将含有干细胞的支架移植到大脑受损区域作为一种治疗策略，碳纳米管在这方面显示出前景，当用作神经细胞和脑组织的支架时，会产生积极的结果。在这里，我们证明用胺修饰的单壁碳纳米管预处理大鼠可以保护神经元并促进诱发中风的大鼠行为功能的恢复。与对照组相比，接受治疗的大鼠表现出更少的组织损伤，并且从旋转杆上摔下来的时间更长，这表明受伤后有更好的运动功能。低水平的细胞凋亡、血管生成和炎症标记物表明胺修饰的单壁碳纳米管可以保护治疗大鼠的大脑免受缺血性损伤。
Stroke results in the disruption of tissue architecture and is the third leading cause of death in the United States. Transplanting scaffolds containing stem cells into the injured areas of the brain has been proposed as a treatment strategy, and carbon nanotubes show promise in this regard, with positive outcomes when used as scaffolds in neural cells and brain tissues. Here, we show that pretreating rats with amine-modified single-walled carbon nanotubes can protect neurons and enhance the recovery of behavioural functions in rats with induced stroke. Treated rats showed less tissue damage than controls and took longer to fall from a rotating rod, suggesting better motor functions after injury. Low levels of apoptotic, angiogenic and inflammation markers indicated that aminemodified single-walled carbon nanotubes protected the brains of treated rats from ischaemic injury.
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影响因子：
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