Infant ultrasonic vocalizations predict adolescent social behavior in rats: Effects of early life adversity.
Infant ultrasonic vocalizations predict adolescent social behavior in rats: Effects of early life adversity.
复制标题
DOI：
10.1002/dev.22260
复制
发表时间：
2022-03
影响因子：
2.2
通讯作者：
中科院分区：
文献类型：
--
作者：
早年逆境（ELA）会增加患精神疾病的风险，这些疾病通常在青春期表现出来，并涉及社会功能紊乱。 ELA 影响前额皮质 (PFC) 的发育，而前额皮质在社会行为中发挥着重要作用。 PFC 催产素和加压素首先是母婴依恋的重要调节剂，其次是社会行为的重要调节剂，并且与精神疾病有关。在这里，我们测试了婴儿社交沟通是否可以预测 PFC 发育和青少年社交行为。我们在出生后 (P)2-14 天的大鼠中使用了有限床上用品 (LB) ELA 模型，并在 P10 时测量了隔离诱导的超声发声 (USV)，以表征早期社会反应的差异。对青春期大鼠进行二元社交互动测试（P34）。在 PFC 中测量青少年催产素受体 (Oxtr) 和精氨酸加压素受体 1a mRNA。评估了婴儿 USV、青少年行为和基因表达之间的关系。 LB 饲养的大鼠在 P10 时表现出较少的 USV。虽然社会行为并没有受到养育的强烈影响，但婴儿 USV 总数和复杂类型的减少预示着青春期互动的减少。 LB 增加了两性的 Oxtr，但 USV 并未直接预测 Oxtr。研究结果支持使用 USV 作为啮齿动物早期生活经历差异的指标，以进一步表征与脆弱性相关的早期因素。
Early life adversity (ELA) increases risk for psychopathologies that often manifest during adolescence and involve disrupted social functioning. ELA affects development of the prefrontal cortex (PFC), which plays a role in social behavior. PFC oxytocin and vasopressin are important regulators of, first, mother–infant attachment, and, later, social behavior, and are implicated in psychiatric disorders. Here, we tested whether infant social communication is predictive of PFC development and adolescent social behavior. We used the limited bedding (LB) ELA model in rats during postnatal days (P)2–14, and measured isolation-induced ultrasonic vocalizations (USVs) at P10 to characterize differences in an early social response. Rats were tested for dyadic social interaction in adolescence (P34). Adolescent oxytocin receptor (Oxtr) and arginine-vasopressin receptor 1a mRNA were measured in the PFC. Relationships between infant USVs, adolescent behavior, and gene expression were assessed. LB-reared rats exhibited fewer USVs at P10. While social behaviors were not robustly affected by rearing, fewer total and complex-type infant USVs predicted fewer interactions in adolescence. LB increased Oxtr in both sexes but Oxtr was not directly predicted by USVs. Findings support the use of USVs as indicators of differential early life experience in rodents, toward further characterization of early factors associated with vulnerability.
登录
查看更多内容
影响因子：
3.3
作者：
Brudzynski SM
通讯作者：
Brudzynski SM
影响因子：
8.2
作者：
Andersen, SL
通讯作者：
Andersen, SL
影响因子：
5
作者：
Bath KG;Nitenson AS;Lichtman E;Lopez C;Chen W;Gallo M;Goodwill H;Manzano-Nieves G
通讯作者：
Manzano-Nieves G
影响因子：
3.4
作者：
Calcagnoli, Federica;de Boer, Sietse F.;Koolhaas, Jaap M.
通讯作者：
Koolhaas, Jaap M.
影响因子：
2.7
作者：
BROUETTELAHLOU, I;VERNETMAURY, E;VIGOUROUX, M
通讯作者：
VIGOUROUX, M