Data-Driven Analysis of Functional Connectivity Reveals a Potential Auditory Verbal Hallucination Network.
Data-Driven Analysis of Functional Connectivity Reveals a Potential Auditory Verbal Hallucination Network.
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DOI：
10.1093/schbul/sby039
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发表时间：
2019-03-07
影响因子：
6.6
通讯作者：
Constable RT
中科院分区：
文献类型：
--
作者：
Scheinost D;Tokoglu F;Hampson M;Hoffman R;Constable RT
精神分裂症是一种严重的全球性健康问题，超过一半的此类患者经历听觉言语幻觉（AVH）。更好地理解区分AVH患者与未经历AVH的患者和健康对照的神经相关性，可以确定导致AVH更好治疗策略的目标。采用2个数据驱动的，基于体素的功能连接性测量，我们研究了46例精神分裂症或情感障碍患者（28例经历AVH，18例未经历AVH）。20名年龄、性别、种族、教育水平、惯用手和估计语言智力相匹配的健康对照者被纳入进行比较。内在连接分布（ICD）用于使用威布尔分布对每个体素与大脑其余部分的连接进行建模。为了研究连接的偏侧化，我们使用了跨半球ICD，这是一种分离每个半球的贡献以询问连接偏侧化的方法。与无AVH的患者相比，AVH患者的内侧前额叶皮层和后扣带回皮层的全脑连接显著降低，左壳核的偏侧连接减少，左额内回的偏侧连接增加。与听觉幻觉评定量表（AHRS）和事后种子连接分析的相关性显示，网络连接显着改变。使用比较患者组和与AHRS相关性的所有分析结果，我们确定了一个潜在的AVH网络，由25个节点组成，与默认模式网络和语言处理网络有很大的重叠。这一网络作为一个整体，而不是单个节点，可能是可采取行动的干预目标。
Schizophrenia is a severe global health problem, with over half of such patients experiencing auditory verbal hallucinations (AVHs). A better understanding of the neural correlates differentiating patients experiencing AVHs from patients not experiencing AVHs and healthy controls may identify targets that lead to better treatment strategies for AVHs. Employing 2 data-driven, voxel-based measure of functional connectivity, we studied 46 patients with schizophrenia or schizoaffective disorder (28 experiencing AVHs and 18 not experiencing AVHs). Twenty healthy controls matched for age, gender, ethnicity, education level, handedness, and estimated verbal intelligence were included for comparison. The intrinsic connectivity distribution (ICD) was used to model each voxel’s connectivity to the rest of the brain using a Weibull distribution. To investigate lateralization of connectivity, we used cross-hemisphere ICD, a method that separates the contribution of each hemisphere to interrogate connectivity laterality. Patients with AVHs compared with patients without AVHs exhibited significantly decreased whole-brain connectivity in the medial prefrontal cortex and posterior cingulate cortex, less lateralized connectivity in left putamen, and more lateralized connectivity in left interior frontal gyrus. Correlations with Auditory Hallucination Rating Scale (AHRS) and post hoc seed connectivity analyses revealed significantly altered network connectivity. Using the results from all analyses comparing the patient groups and correlations with AHRS, we identified a potential AVH network, consisting of 25 nodes, showing substantial overlap with the default mode network and language processing networks. This network as a whole, instead of individual nodes, may represent actionable targets for interventions.
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影响因子：
5.7
作者：
Constable, R. Todd;Vohr, Betty R.;Scheinost, Dustin;Benjamin, Jennifer R.;Fulbright, Robert K.;Lacadie, Cheryl;Schneider, Karen C.;Katz, Karol H.;Zhang, Heping;Papademetris, Xenophon;Ment, Laura R.
通讯作者：
Ment, Laura R.
影响因子：
3.1
作者：
Clos M;Diederen KM;Meijering AL;Sommer IE;Eickhoff SB
通讯作者：
Eickhoff SB
影响因子：
6.6
作者：
Ben-Zeev, Dror;Morris, Scott;Granholm, Eric
通讯作者：
Granholm, Eric
影响因子：
14.5
作者：
Gotts, Stephen J.;Simmons, W. Kyle;Martin, Alex
通讯作者：
Martin, Alex
影响因子：
4.7
作者：
Cho R;Wu W
通讯作者：
Wu W