Jump exercise during hindlimb unloading protect against the deterioration of trabecular bone microarchitecture in growing young rats.
Jump exercise during hindlimb unloading protect against the deterioration of trabecular bone microarchitecture in growing young rats.
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DOI：
10.1186/2193-1801-2-35
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Fukunaga M
中科院分区：
文献类型：
--
作者：
Ju YI;Sone T;Ohnaru K;Choi HJ;Choi KA;Fukunaga M
研究了悬尾幼鼠的三维股骨小梁结构，并检查了悬尾期间跳跃运动的影响。 8周龄雄性Wistar大鼠（n = 24）被随机分为三个体重匹配组：悬尾组（SUS，n = 8）；久坐对照组（CON，n = 8）和在悬尾期间进行跳跃运动的大鼠（JUM，n = 8）。跳跃练习方案包括每周 5 天、每天 30 次跳跃，跳跃高度为 40 厘米。经过3周的跳跃运动后，使用双能X射线吸收仪测量整个右股骨的骨矿物质密度（BMD）。使用微计算机断层扫描（micro-CT）评估股骨远端干骺端的三维骨小梁结构。尾部悬吊导致股骨 BMD 下降（−5%，p< 0.001）和小梁骨结构恶化。后肢卸载期间小梁网络的恶化主要归因于股骨远端干骺端中小梁数量的减少（-32%，p<0.001）。悬尾期间的跳跃运动增加了小梁厚度（14％，p< 0.001），并且抑制了小梁数量的减少。目前的数据表明，在后肢卸载过程中进行跳跃运动可以抑制尾悬吊引起的骨质流失和骨小梁结构恶化。
Three-dimensional femoral trabecular architecture was investigated in tail-suspended young growing rats and the effects of jump exercise during the period of tail-suspension were also examined. Eight-week-old male Wistar rats (n = 24) were randomly assigned to three body weight-matched groups: a tail suspended group (SUS, n = 8); a sedentary control group (CON, n = 8) and rats primed with jump exercise during the period of tail suspension (JUM, n = 8). The jump exercise protocol consisted of 30 jumps/day, five days/week with a 40 cm jump height. After 3 weeks of jump exercise, bone mineral density (BMD) of the entire right femur was measured using dual energy X-ray absorptiometry. Three-dimensional trabecular bone architecture at the distal femoral metaphysis was evaluated using microcomputed tomography (micro-CT). Tail suspension caused a decrease in femoral BMD (−5%, p < 0.001) and trabecular bone architectural deterioration. Deterioration in the trabecular network during hindlimb unloading was mostly attributed to the reduction of trabecular number (−32%, p < 0.001) in the distal femoral metaphysis. Jump exercise during the tail suspension period increased trabecular thickness (14%, p < 0.001) and the reduction of trabecular number was suppressed. The present data indicate that jump exercise applied during hindlimb unloading could be able to inhibit bone loss and trabecular bone architectural deterioration caused by tail suspension.
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影响因子：
4.2
作者：
Tezval, M.;Biblis, M.;Sehmisch, S.;Schmelz, U.;Kolios, L.;Rack, T.;Stuermer, K. M.;Stuermer, E. K.
通讯作者：
Stuermer, E. K.
影响因子：
4.1
作者：
Ito, M;Nishida, A;Hayashi, K
通讯作者：
Hayashi, K
影响因子：
4.1
作者：
Rittweger, J;Frost, HM;Felsenberg, D
通讯作者：
Felsenberg, D
影响因子：
6.2
作者：
Fuchs, RK;Bauer, JJ;Snow, CM
通讯作者：
Snow, CM
影响因子：
6.2
作者：
Armbrecht, Gabriele;Belavy, Daniel Ludovic;Felsenberg, Dieter
通讯作者：
Felsenberg, Dieter