Improvement of femoral bone quality after low-magnitude, high-frequency mechanical stimulation in the ovariectomized rat as an osteopenia model.
Improvement of femoral bone quality after low-magnitude, high-frequency mechanical stimulation in the ovariectomized rat as an osteopenia model.
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DOI：
10.1007/s00223-010-9423-7
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发表时间：
2011-01
影响因子：
4.2
通讯作者：
Stuermer, E. K.
中科院分区：
文献类型：
--
作者：
Tezval, M.;Biblis, M.;Sehmisch, S.;Schmelz, U.;Kolios, L.;Rack, T.;Stuermer, K. M.;Stuermer, E. K.
骨质疏松症的治疗和预防面临着巨大的挑战。非药物和支持治疗程序、运动和体育锻炼似乎可以防止骨质流失并提高骨量。在本研究中，我们研究了全身垂直振动（WBVV）对大鼠骨质疏松模型中股骨粗隆间骨质量的影响。 60 只 3 个月大的雌性 Sprague-Dawley 大鼠被切除卵巢 (OVX) 或进行假手术。 3个月后，每组又分为两个亚组。在其中一个亚组中，大鼠接受 90 Hz（3.9 g）的 WBVV 治疗 35 天；第二组仍未得到治疗。处死动物后，分析股骨近端区域的生物力学强度和骨小梁结构。另外还测量了股骨的新皮质骨并置和矿物质密度。 WBVV 治疗改善了生物力学特性。 WBVV 后股骨转子间区域的最大载荷和刚度显着增强。经治疗的 OVX 动物的最大负荷和硬度达到未治疗的假大鼠中观察到的水平。 WBVV 显着改善了小梁区域所有测量的组织形态学参数。与未经治疗的动物相比，经过治疗的大鼠股骨灰中的矿物质含量显着提高。 WBVV 后，转子下横截面皮质骨中荧光带宽度的比较没有显示各组之间存在任何显着差异。低强度、高频机械刺激可改善股骨近端的骨强度，可能是绝经后骨质疏松症的一种可能的非药物治疗选择。
The treatment and prevention of osteoporosis involve great challenges. Nonpharmacological and supportive therapy procedures, sport, and physical exercises seem to prevent bone loss and improve bone mass. In the present study, we examined the effect of whole-body vertical vibration (WBVV) on femoral intertrochanteric bone quality in the rat osteoporosis model. Sixty female Sprague–Dawley rats, 3-month old, were ovariectomized (OVX) or sham-operated. After 3 months, each group was divided into two subgroups. In one of the subgroups, rats were treated with WBVV at 90 Hz (3.9 g) for 35 days; the second subgroup remained untreated. After killing the animals, biomechanical strength and trabecular bone architecture of the proximal region of femurs were analyzed. New cortical bone appositions and mineral density of femurs were additionally measured. Treatment with WBVV resulted in improved biomechanical properties. Maximal load and stiffness of the intertrochanteric region of femurs after WBVV were significantly enhanced. Maximal load and stiffness in treated OVX animals reached the levels observed in untreated sham rats. WBVV significantly improved all measured histomorphometric parameters in the trabecular area. Treated rats showed significantly improved mineral content in ashed femurs compared to untreated animals. A comparison of widths of fluorescence bands in cortical bone of subtrochanteric cross sections did not show any significant differences between the groups after WBVV. Low-magnitude, high-frequency mechanical stimulation improves bone strength in the proximal femur and may be a possible nonpharmacologic treatment option for postmenopausal osteoporosis.
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影响因子：
6.2
作者：
Torvinen, S;Kannus, P;Vuori, I
通讯作者：
Vuori, I
影响因子：
6.1
作者：
Ruan Xiang-yan;Jin Feng-yu;Sun Yun-gao
通讯作者：
Sun Yun-gao
DOI：
10.1243/09544119jeim439
发表时间：
2008-10-01
影响因子：
1.8
作者：
Aleyaasin, M.;Harrigan, J. J.
通讯作者：
Harrigan, J. J.
影响因子：
2.3
作者：
Gusi, Narcis;Raimundo, Armando;Leal, Alejo
通讯作者：
Leal, Alejo
影响因子：
4.2
作者：
Flieger, J;Karachalios, T;Lyritis, G
通讯作者：
Lyritis, G