The dynamics of vein graft remodeling induced by hemodynamic forces: a mathematical model.
The dynamics of vein graft remodeling induced by hemodynamic forces: a mathematical model.
复制标题
DOI：
10.1007/s10237-011-0321-3
复制
发表时间：
2012-03
影响因子：
3.5
通讯作者：
Tran-Son-Tay R
中科院分区：
文献类型：
--
作者：
Hwang M;Berceli SA;Garbey M;Kim NH;Tran-Son-Tay R
尽管静脉旁路移植术是治疗动脉闭塞性疾病的主要选择之一，并且在治疗的早期阶段提供了令人满意的结果，但许多患者的通畅时间仅限于几个月。当静脉植入动脉系统时，它通过改变其各层的大小来适应动脉环境的高流速和高压，这种重塑被认为是未来移植失败的先兆。血流动力学力，例如壁剪切应力（WSS）和壁张力，已被认为是影响静脉移植物重塑的主要因素。尽管已报道了与血流动力学力与静脉移植物重塑相关的广泛实验证据，但仍缺乏描述 WSS、壁张力和静脉移植物壁各层结构适应之间关系的综合数学模型。当前的手稿提出了一个全面而强大的框架，用于处理 WSS、壁张力和静脉移植壁每个单独层的结构适应之间的复杂相互作用。我们对内膜和内侧区域以及外部弹性层的半径进行了建模，它们共同决定了管腔变窄和移植物闭塞的倾向。我们模型的核心是自变量和因变量之间的逻辑关系，用于描述增长率的初始增长和后来的下降。从当前模型中提取的对静脉移植物形态随时间变化的详细了解对于确定静脉移植物失败的主要原因以及进一步制定提高其寿命的策略至关重要。
Although vein bypass grafting is one of the primary options for the treatment of arterial occlusive disease and provides satisfactory results at an early stage of the treatment, the patency is limited to a few months in many patients. When the vein is implanted in the arterial system, it adapts to the high flow rate and high pressure of the arterial environment by changing the sizes of its layers, and this remodeling is believed to be a precursor of future graft failure. Hemodynamic forces, such as wall shear stress (WSS) and wall tension, have been recognized as major factors impacting vein graft remodeling. Although a wide range of experimental evidence relating hemodynamic forces to vein graft remodeling has been reported, a comprehensive mathematical model describing the relationship among WSS, wall tension, and the structural adaptation of each individual layer of the vein graft wall is lacking. The current manuscript presents a comprehensive and robust framework for treating the complex interaction between the WSS, wall tension, and the structural adaptation of each individual layer of the vein graft wall. We modeled the intimal and medial area and the radius of external elastic lamina, which in combination dictate luminal narrowing and the propensity for graft occlusion. Central to our model is a logistic relationship between independent and dependent variables to describe the initial increase and later decrease in the growth rate. The detailed understanding of the temporal changes in vein graft morphology that can be extracted from the current model is critical in identifying the dominant contributions to vein graft failure and the further development of strategies to improve their longevity.
登录
查看更多内容
DOI：
10.1152/ajpheart.00268.2009
发表时间：
2009-10-01
影响因子：
4.8
作者：
Jiang, Zhihua;Tao, Ming;Berceli, Scott A.
通讯作者：
Berceli, Scott A.
影响因子：
2.2
作者：
SUMPIO, BE;BANES, AJ
通讯作者：
BANES, AJ
DOI：
10.1152/ajpheart.00760.2003
发表时间：
2004-01-01
影响因子：
4.8
作者：
Jiang, ZH;Wu, LZ;Berceli, SA
通讯作者：
Berceli, SA
影响因子：
3.5
作者：
Alford, Patrick W.;Humphrey, Jay D.;Taber, Larry A.
通讯作者：
Taber, Larry A.
影响因子：
5.3
作者：
FRIEDMAN, MH;DETERS, OJ;MARK, FF
通讯作者：
MARK, FF