A ferulic acid derivative, ethyl 3-(4'-geranyloxy-3-methoxyphenyl)-2-propenoate, as a new candidate chemopreventive agent for colon carcinogenesis in the rat.
A ferulic acid derivative, ethyl 3-(4'-geranyloxy-3-methoxyphenyl)-2-propenoate, as a new candidate chemopreventive agent for colon carcinogenesis in the rat.
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DOI：
10.1111/j.1349-7006.2001.tb01109.x
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发表时间：
2001-04
期刊：
影响因子：
--
通讯作者：
Tsuda H
中科院分区：
文献类型：
--
作者：
Han BS;Park CB;Takasuka N;Naito A;Sekine K;Nomura E;Taniguchi H;Tsuno T;Tsuda H
在雄性F344大鼠中研究了阿魏酸（FA）（一种米胚芽成分）及其香叶基化衍生物3-（4′-香叶基氧基-3-甲氧基苯基）-2-丙烯酸酯（EGMP）对氧化偶氮甲烷（AOM）诱导的结肠癌发生后起始阶段的抑制作用。在第1周期间注射AOM（15 mg/kg体重）。然后从第2周至第5周喂食含有0.1或0.2%剂量的EGMP或FA的饲料3周，此时处死动物。与AOM单独给药组相比，0.2%FA给药组每只大鼠的畸变隐窝病灶（ACF）和畸变隐窝（AC）数量显著减少（P<0.001）。此外，0.2%和0.1% EGMP组大鼠的ACF和AC数量显著减少（分别为P<0.001和P<0.01）。与AOM单独给药组相比，0.2%和0.1% EGMP给药组大鼠结肠S期上皮细胞（通过溴脱氧尿苷（BrdU）标记测量）显著减少（P<0.05）。与AOM单独给药值相比，FA和EGMP给药大鼠的BrdU标记指数也显著降低（分别为P<0.05，P<0.01）。结果表明，FA和EGMP对ACF和AC的发展有抑制作用，EGMP更有效，可能是由于对细胞增殖的抑制作用更强。在给予任一化合物的大鼠中，在体重和器官重量以及肝脏或肾脏组织学方面均未观察到毒性作用。因此，研究结果表明，EGMP和FA，特别是前者，可能有潜力作为化学预防剂对结肠肿瘤的发展。
The inhibitory influence of ferulic acid (FA), a rice germ component, and its geranylated derivative 3‐(4′‐geranyloxy‐3‐methoxyphenyl)‐2‐propenoate (EGMP) on the post‐initiation stage of azoxy‐methane (AOM)‐induced colon carcinogenesis was studied in male F344 rats given two s.c. injections of AOM (15 mg/kg body weight) during week 1. Diets containing EGMP or FA at doses of 0.1 or 0.2% were then fed for 3 weeks from week 2 to 5, when the animals were sacrificed. The numbers of aberrant crypt foci (ACF) and aberrant crypts (AC) per rat in the group given 0.2% FA were significantly decreased (P<0.001) as compared to the AOM alone group. Furthermore, the numbers of ACF and AC per rat fed the 0.2% and 0.1% EGMP were significantly reduced (P<0.001 and P<0.01, respectively). Colonic epithelial cells in S‐phase, as measured by bromodeoxy‐uridine (BrdU) labeling, in rats fed EGMP were significantly decreased in the 0.2 and 0.1% EGMP groups as compared to the AOM alone group (P<0.05). BrdU labeling indices in rats fed FA and EGMP assessed by a test using a coefficient for linear contrast were also significantly decreased as compared to the AOM alone value (P<0.05, P<0.01, respectively). The results indicate that FA and EGMP have inhibitory effects on ACF and AC development, EGMP being more potent, possibly due to stronger suppressive effects on cell proliferation. No toxic effects were observed in rats given either compound in terms of body and organ weights, and liver or kidney histology. The findings thus suggest that EGMP and FA, especially the former, might have potential as chemopreventive agents against colon tumor development.
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影响因子：
2.9
作者：
CHEN, MF;CHEN, LT;BOYCE, HW
通讯作者：
BOYCE, HW
DOI：
10.1007/bf01644245
发表时间：
1971-01-01
期刊：
ZEITSCHRIFT FUR LEBENSMITTEL-UNTERSUCHUNG UND-FORSCHUNG
影响因子：
--
作者：
HEIMANN, W;HERMANN, K;FEUCHT, G
通讯作者：
FEUCHT, G
DOI：
10.1080/00021369.1977.10862745
发表时间：
1977-01-01
期刊：
AGRICULTURAL AND BIOLOGICAL CHEMISTRY
影响因子：
--
作者：
FUJIMAKI, M;TSUGITA, T;KURATA, T
通讯作者：
KURATA, T
影响因子：
2.9
作者：
DeneoPellegrini, H;DeStefani, E;Ronco, A
通讯作者：
Ronco, A
影响因子：
9.7
作者：
BIRD, RP
通讯作者：
BIRD, RP