Influence of dietary pattern on anti-tuberculosis treatment outcomes in persons with dysglycemia: a Peruvian prospective cohort study.
Influence of dietary pattern on anti-tuberculosis treatment outcomes in persons with dysglycemia: a Peruvian prospective cohort study.
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DOI：
10.3389/fnut.2023.1254983
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发表时间：
2023
影响因子：
5
通讯作者：
Andrade, Bruno B.
中科院分区：
文献类型：
--
作者：
Arriaga, Maria B.;Araujo-Pereira, Mariana;Andrade, Vanessa M. B.;Queiroz, Artur T. L.;Fernandes, Catarina D.;Sales, Caio;Aliaga, Juan Gonzalo;Shivakoti, Rupak;Lecca, Leonid;Calderon, Roger I.;Andrade, Bruno B.
饮食模式(DPS)与总体营养状况相关，并可能改变结核病的临床预后。这种相互作用可以通过血糖紊乱(即糖尿病或糖尿病前期)进一步复杂化。在这里，我们确定了更常见的肺结核-血糖异常的DPS，并描述了它们与结核病治疗结果的关系。在秘鲁对结核病患者及其接触者进行了一项前瞻性队列研究。食物频率问卷和基于多维系统生物学的分析方法被用来确定与这些临床群体相关的DPS。分析了临床特征和DPS之间潜在的独立联系。确定了三个主要的DPS。TB-血糖异常病例更常摄入高碳水化合物(DP1)。此外，研究发现，DP1与独立于其他因素(包括血糖异常)的不良结核病结局风险增加有关。我们的发现表明，通过DPS评估诸如血糖异常等合并症的营养状况是预测结核病治疗结果的基本行动。高碳水化合物摄入量、血糖异常和不利的结核病治疗结果之间的关联机制值得进一步研究。
Dietary patterns (DPs) are associated with overall nutritional status and may alter the clinical prognosis of tuberculosis. This interaction can be further intricated by dysglycemia (i.e., diabetes or prediabetes). Here, we identified DPs that are more common with tuberculosis–dysglycemia and depicted their association with tuberculosis treatment outcomes. A prospective cohort study of persons with tuberculosis and their contacts was conducted in Peru. A food frequency questionnaire and a multidimensional systems biology-based analytical approach were employed to identify DPs associated with these clinical groups. Potential independent associations between clinical features and DPs were analyzed. Three major DPs were identified. TB–dysglycemia cases more often had a high intake of carbohydrates (DP1). Furthermore, DP1 was found to be associated with an increased risk of unfavorable TB outcomes independent of other factors, including dysglycemia. Our findings suggest that the evaluation of nutritional status through DPs in comorbidities such as dysglycemia is a fundamental action to predict TB treatment outcomes. The mechanisms underlying the association between high intake of carbohydrates, dysglycemia, and unfavorable tuberculosis treatment outcomes warrant further investigation.
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DOI：
10.1016/j.jctube.2021.100279
发表时间：
2021-12
影响因子：
2
作者：
Alayu Alemu M;Yesuf A;Girma F;Adugna F;Melak K;Biru M;Seyoum M;Abiye T
通讯作者：
Abiye T
影响因子：
6.4
作者：
Arriaga, Maria B.;Araujo-Pereira, Mariana;Andrade, Bruno B.
通讯作者：
Andrade, Bruno B.
影响因子：
7.1
作者：
Jakobsen, Marianne U.;Dethlefsen, Claus;Overvad, Kim
通讯作者：
Overvad, Kim
影响因子：
3.9
作者：
Krawinkel, M. B.
通讯作者：
Krawinkel, M. B.
影响因子：
5.9
作者：
Musuenge BB;Poda GG;Chen PC
通讯作者：
Chen PC