Increased expression of stress inducible protein 1 in glioma-associated microglia/macrophages.
Increased expression of stress inducible protein 1 in glioma-associated microglia/macrophages.
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DOI：
10.1016/j.jneuroim.2014.06.021
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发表时间：
2014-09-15
影响因子：
3.3
通讯作者：
Badie, Behnam
中科院分区：
文献类型：
--
作者：
Carvalho da Fonseca, Anna Carolina;Wang, Huaqing;Fan, Haitao;Chen, Xuebo;Zhang, Ian;Zhang, Leying;Lima, Flavia Regina Souza;Badie, Behnam
关键词：
胶质瘤相关的小胶质细胞/巨噬细胞（GAM）释放的因子在肿瘤的生长和浸润中起重要作用。我们以前已经证明，辅伴侣应激诱导蛋白1（STI 1）分泌的小胶质细胞促进增殖和迁移的人胶质母细胞瘤（GBM）细胞系在体外。在本研究中，为了研究STI 1在生理环境中的作用，我们使用胶质瘤模型来评估STI 1在体内的表达。在这里，我们证明了STI 1在肿瘤和浸润性GAM和淋巴细胞中的表达随肿瘤进展而显著增加。有趣的是，在浸润脑肿瘤的巨噬细胞和淋巴细胞中观察到STI 1的高表达，而在循环血液单核细胞和淋巴细胞中的STI 1表达保持不变。我们的研究结果首次将STI 1的表达与胶质瘤进展相关联，并表明STI 1在GAM和浸润淋巴细胞中的表达受到脑肿瘤微环境的调节。
Factors released by glioma-associated microglia/macrophages (GAMs) play an important role in the growth and infiltration of tumors. We have previously demonstrated that the co-chaperone stress-inducible protein 1 (STI1) secreted by microglia promotes proliferation and migration of human glioblastoma (GBM) cell lines in vitro. In the present study, in order to investigate the role of STI1 in a physiological context, we used a glioma model to evaluate STI1 expression in vivo. Here, we demonstrate that STI1 expression in both the tumor and in the infiltrating GAMs and lymphocytes significantly increased with tumor progression. Interestingly, high expression of STI1 was observed in macrophages and lymphocytes that infiltrated brain tumors, whereas STI1 expression in the circulating blood monocytes and lymphocytes remained unchanged. Our results correlate, for the first time, the expression of STI1 and glioma progression, and suggest that STI1 expression in GAMs and infiltrating lymphocytes is modulated by the brain tumor microenvironment.
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影响因子：
4.8
作者：
Cargnin, F;Flora, A;Fornasari, D
通讯作者：
Fornasari, D
影响因子：
3.3
作者：
da Fonseca, A. C. C.;Romao, L.;Lima, F. R. S.
通讯作者：
Lima, F. R. S.
影响因子：
3.5
作者：
Hartmann, Camila Arantes;Martins, Vilma Regina;Souza Lima, Flavia Regina
通讯作者：
Souza Lima, Flavia Regina
影响因子：
3.7
作者：
Kim, Sunghoon;Cho, HanByoul;Kim, Jae-Hoon
通讯作者：
Kim, Jae-Hoon
影响因子：
3.3
作者：
Badie, B;Bartley, B;Schartner, J
通讯作者：
Schartner, J