Hyper-coupling between working memory task-evoked activations and amplitude of spontaneous fluctuations in first-episode schizophrenia
Hyper-coupling between working memory task-evoked activations and amplitude of spontaneous fluctuations in first-episode schizophrenia
复制标题
首发精神分裂症工作记忆任务诱发激活与自发波动幅度之间的超耦合
DOI：
10.1016/j.schres.2014.07.023
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发表时间：
2014-10
影响因子：
4.5
通讯作者：
Liu, Zhening
中科院分区：
文献类型：
--
作者：
Zhang, Huiran;Wang, Yun;Jiang, Tianzi;Liu, Zhening
工作记忆(WM)缺陷是精神分裂症患者认知损害的重要组成部分。然而，关于特定功能底物的研究之间的不一致表明，精神分裂症患者西医表现的个体间变异性(IIV)与脑活动的IIV相关。为了检查这种WM IIV的神经基础，我们研究了精神分裂症患者和健康人的WM能力个体差异背后的神经机制是否相同。我们将n-back WM任务中任务诱发的脑活动和任务绩效的IIV与通过低频波动幅度(ALFF)测量的内在静息状态活动的时刻到时刻变异性的IIV相关联，并进一步比较了17例首发精神分裂症(FES)患者和18名健康对照之间的这种关系。相关模式的组间比较表明，在FES患者中，Alff-WM激活相关性和Alff-WM性能相关性异常，但在这三个特征的任何一项测量中均未检测到显著变化。具体地说，我们发现在FES患者的双侧外侧前额叶皮质、后顶叶皮质和梭形回中，Alff-WM激活相关性增加。我们还观察到FES患者双侧腹内侧前额叶皮质Alff-WM表现的正相关性显著增加。在WM任务中，Alff和fMRI测量之间的这种高度耦合可能表明，患者很难将自己从一种状态分离到另一种状态，并表明精神分裂症患者低效的皮质功能源于大脑的内在功能架构。
Working memory (WM) deficit is an important component of impaired cognition in schizophrenia. However, between-studies inconsistencies as to the specific functional substrate imply that inter-individual variability (IIV) in the WM performance is associated with IIV in brain activity in schizophrenia. To examine the neural substrate of this WM IIV, we studied whether the neural mechanisms that underlie individual differences in WM capacity are the same in schizophrenia patients and healthy people. We correlated the IIV of the task-evoked brain activity and task performance during an n-back WM task with the IIV of the moment-to-moment variability in intrinsic resting-state activity, as measured by the amplitude of low-frequency fluctuations (ALFFs) and further compared this relationship between 17 patients with first-episode schizophrenia (FES) and 18 healthy controls. Between-group comparisons of the correlation patterns indicated aberrant ALFF-WM activation correlations and ALFF-WM performance correlations in the FES patients, but no significant changes were detected in any single measurement of these three characteristics. Specifically, we found increased positive ALFF-WM activation correlations in the bilateral lateral prefrontal cortices, posterior parietal cortices and fusiform gyri in the FES patients. We also observed significant increases in positive ALFF-WM performance correlations in the bilateral ventromedial prefrontal cortices in the FES patients. This hyper-coupling between the ALFF and fMRI measures during a WM task may indicate that it was difficult for the patients to detach themselves from one state to transition to another and suggests that the inefficient cortical function in schizophrenia stems from the intrinsic functional architecture of the brain.
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首次接受治疗的精神分裂症患者异常的内在大脑活动和认知缺陷
影响因子：
6.9
作者：
He, Z.;Deng, W.;Li, T.
通讯作者：
Li, T.
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
2.5
作者：
D'Esposito, M;Postle, BR;Lease, J
通讯作者：
Lease, J
DOI：
10.1523/jneurosci.2987-11.2011
发表时间：
2011-09
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
R. Salomon;M. Bleich-Cohen;Avital Hahamy-Dubossarsky;Ilan Dinstien;R. Weizman;M. Poyurovsky;M. Kupchik;M. Kotler;T. Hendler;R. Malach
通讯作者：
R. Salomon;M. Bleich-Cohen;Avital Hahamy-Dubossarsky;Ilan Dinstien;R. Weizman;M. Poyurovsky;M. Kupchik;M. Kotler;T. Hendler;R. Malach