Insufficient and excessive amounts of sleep increase the risk of premature death from cardiovascular and other diseases: the Multiethnic Cohort Study.

Insufficient and excessive amounts of sleep increase the risk of premature death from cardiovascular and other diseases: the Multiethnic Cohort Study.
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DOI:
10.1016/j.ypmed.2013.06.017
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发表时间:
2013-10
影响因子:
5.1
通讯作者:
Goodman, Marc T.
Goodman, Marc T.
中科院分区:
医学2区
文献类型:
--
作者:
Kim, Yeonju;Wilkens, Lynne R.;Schembre, Susan M.;Henderson, Brian E.;Kolonel, Laurence N.;Goodman, Marc T.

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探讨自我报告的睡眠时间与特定原因死亡率之间的独立关联。数据来自在洛杉矶和夏威夷进行的多种族队列研究。在平均 12.9 年的随访期间,在没有癌症、心脏病或中风病史的 61,936 名男性和 73,749 名女性中,有 19,335 人死亡。睡眠时间较短(≤5 小时/天)和较长(≥9 小时/天)的男女(相对于每天 7 小时)的全因死亡率和心血管疾病 (CVD) 死亡率增加,但癌症死亡率则没有增加。男性中,≤5 小时/天的 CVD 死亡率的多变量风险比为 1.13 (95% CI 1.00-1.28),≥9 小时/天的 CVD 死亡率的多变量风险比为 1.22 (95% CI 1.09-1.35);女性中,≤5 小时/天为 1.20(95% CI 1.05-1.36),≥9 小时/天为 1.29(95% CI 1.13-1.47)。在男性 (Phetero 0.53) 或女性 (Phetero 0.72) 中,这种风险模式在 CVD 死亡的具体原因上并无异质性。在研究中包括的所有五个种族群体以及年龄、吸烟状况和体重指数亚组中均观察到全因死亡率和心血管疾病死亡率之间的 U 形关联。在多种族人群中,睡眠不足或过多与心血管疾病和其他疾病导致的死亡风险增加有关。
To explore an independent association between self-reported sleep duration and cause-specific mortality. Data were obtained from the Multiethnic Cohort Study conducted in Los Angeles and Hawaii. Among 61,936 men and 73,749 women with no history of cancer, heart attack or stroke, 19,335 deaths occurred during an average 12.9 year follow-up. Shorter (≤5 h/day) and longer (≥9 h/day) sleepers of both sexes (vs. 7 h/day) had an increased risk of all-cause and cardiovascular disease (CVD) mortality, but not of cancer mortality. Multivariable hazard ratios for CVD mortality were 1.13 (95% CI 1.00-1.28) for ≤5 h/day and 1.22 (95% CI 1.09-1.35) for ≥9 h/day among men; and 1.20 (95% CI 1.05-1.36) for ≤5 h/day and 1.29 (95% CI 1.13-1.47) for ≥9 h/day among women. This risk pattern was not heterogeneous across specific causes of CVD death among men (Phetero 0.53) or among women (Phetero 0.72). The U-shape association for all-cause and CVD mortality was observed in all five ethnic groups included in the study and by subgroups of age, smoking status, and body mass index. Insufficient or excessive amounts of sleep were associated with increased risk of mortality from CVD and other diseases in a multiethnic population.
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