Make war not love: The neural substrate underlying a state-dependent switch in female social behavior.
Make war not love: The neural substrate underlying a state-dependent switch in female social behavior.
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DOI：
10.1016/j.neuron.2021.12.002
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发表时间：
2022-03-02
期刊：
影响因子：
16.2
通讯作者：
Anderson DJ
中科院分区：
文献类型：
--
作者：
Liu M;Kim DW;Zeng H;Anderson DJ
雌性小鼠表现出相反的社会行为对男性，这取决于他们的生殖状态：处女显示性接受（脊柱前凸行为），而哺乳期的母亲攻击。生殖状态的改变如何在对同种刺激的行为反应中产生质的转变尚不清楚。使用单细胞RNAseq，我们确定了两个不同的亚型雌激素受体-1（Esr 1）阳性神经元的腹外侧亚部的女性腹内侧下丘脑（VMHvl），并证明他们因果控制性的接受性和侵略性的处女和哺乳期的母亲，分别。从每个亚型之间和受试者内的散装钙记录显示，侵略特定的细胞获得从童贞到母性的过渡期间增加的社会线索的反应，而交配特定的人口的反应似乎没有变化。这些结果表明，转录不同的神经亚型的相对活性的生殖状态依赖性变化可以作为与生理状态变化相关的行为的分类开关的基础。内部状态可以深刻地改变释放刺激的先天行为反应。Liu等人鉴定了单个下丘脑核（VMHvl）内的不同神经亚群，其因果地控制雌性交配与攻击行为。亚群相对线索敏感性的变化是社会行为状态依赖性转换的基础。
Female mice exhibit opposing social behaviors towards males, depending on their reproductive state: virgins display sexual receptivity (lordosis behavior), while lactating mothers attack. How a change in reproductive state produces a qualitative switch in behavioral response to the same conspecific stimulus is unknown. Using single-cell RNAseq, we identify two distinct subtypes of Estrogen receptor-1 (Esr1)-positive neurons in the ventrolateral subdivision of the female ventromedial hypothalamus (VMHvl), and demonstrate that they causally control sexual receptivity and aggressiveness in virgins and lactating mothers, respectively. Between- and within-subject bulk calcium recordings from each subtype reveal that the aggression-specific cells acquire an increased responsiveness to social cues during the transition from virginity to maternity, while the responsiveness of the mating-specific population appears unchanged. These results demonstrate that reproductive state-dependent changes in the relative activity of transcriptomically distinct neural subtypes can underlie categorical switches in behavior associated with physiological state changes. Internal states can profoundly alter innate behavioral responses to releasing stimuli. Liu et al. identify distinct neural subpopulations within a single hypothalamic nucleus (VMHvl) that causally control female mating vs. aggressive behaviors. Changes in the subpopulations’ relative cue sensitivity underlies a state-dependent switch in social behaviors.
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影响因子：
64.8
作者：
Karigo T;Kennedy A;Yang B;Liu M;Tai D;Wahle IA;Anderson DJ
通讯作者：
Anderson DJ
影响因子：
64.8
作者：
通讯作者：
--
下丘脑腹内侧的 Esr1( ) 细胞控制女性攻击性
影响因子：
25
作者：
Hashikawa K;Hashikawa Y;Tremblay R;Zhang J;Feng JE;Sabol A;Piper WT;Lee H;Rudy B;Lin D
通讯作者：
Lin D
影响因子：
25
作者：
Boyden, ES;Zhang, F;Deisseroth, K
通讯作者：
Deisseroth, K
影响因子：
16.6
作者：
Oliveira VEM;Lukas M;Wolf HN;Durante E;Lorenz A;Mayer AL;Bludau A;Bosch OJ;Grinevich V;Egger V;de Jong TR;Neumann ID
通讯作者：
Neumann ID