A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body.
A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body.
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运动引起的全身抗炎和老年保护作用的单细胞转录组图谱
DOI：
10.1016/j.xinn.2023.100380
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发表时间：
2023-01-30
期刊：
影响因子：
32.1
通讯作者：
Liu, Guang-Hui
中科院分区：
文献类型：
--
作者：
Sun, Shuhui;Ma, Shuai;Cai, Yusheng;Wang, Si;Ren, Jie;Yang, Yuanhan;Ping, Jiale;Wang, Xuebao;Zhang, Yiyuan;Yan, Haoteng;Li, Wei;Esteban, Concepcion Rodriguez;Yu, Yan;Liu, Feifei;Belmonte, Juan Carlos Izpisua;Zhang, Weiqi;Qu, Jing;Liu, Guang-Hui
运动有益于整个机体，然而，全身组织如何协调地对运动做出反应仍然是个谜。在这里，在年轻和年老的小鼠中，有或没有运动，并暴露于感染性损伤，我们以单细胞分辨率表征了14个组织/器官对12个月运动的表型和分子适应。总体而言，运动保护组织免受感染性损伤，尽管在年轻动物中更有效，并且在炎症抑制和组织再生方面对老年人有益，其中中枢神经系统和全身血管系统的结构改善最为突出。在血管内皮细胞中，我们发现通过核心生物钟蛋白BMAL 1重新调整节律机制可以延缓衰老，促进感染性损伤的恢复，重现运动的有益作用。我们的研究强调了运动在重建年轻生物钟网络中的作用，并为进一步研究整个生物体中运动，衰老和免疫挑战之间的相互作用提供了基础。长期锻炼对年龄、组织和细胞类型的特定益处图谱。运动可以保护组织免受感染性损伤，特别是在年轻人身上。运动促进衰老组织的再生，特别是神经系统。运动发挥老年保护作用，特别是通过生物钟蛋白BMAL 1重置昼夜节律程序。
Exercise benefits the whole organism, yet, how tissues across the body orchestrally respond to exercise remains enigmatic. Here, in young and old mice, with or without exercise, and exposed to infectious injury, we characterized the phenotypic and molecular adaptations to a 12-month exercise across 14 tissues/organs at single-cell resolution. Overall, exercise protects tissues from infectious injury, although more effectively in young animals, and benefits aged individuals in terms of inflammaging suppression and tissue rejuvenation, with structural improvement in the central nervous system and systemic vasculature being the most prominent. In vascular endothelial cells, we found that readjusting the rhythmic machinery via the core circadian clock protein BMAL1 delayed senescence and facilitated recovery from infectious damage, recapitulating the beneficial effects of exercise. Our study underscores the effect of exercise in reconstituting the youthful circadian clock network and provides a foundation for further investigating the interplay between exercise, aging, and immune challenges across the whole organism. An atlas of age-, tissue-, and cell-type-specific benefits of long-term exercise. Exercise protects tissues from infectious injury, especially in younger ones. Exercise promotes rejuvenation in aged tissues, especially in the nervous system. Exercise exerts geroprotective effects, especially by resetting circadian programs via the circadian clock protein BMAL1.
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昼夜节律对衰老和寿命的重要性。
影响因子：
16.6
作者：
Acosta-Rodríguez VA;Rijo-Ferreira F;Green CB;Takahashi JS
通讯作者：
Takahashi JS
运动和PGC1alpha在炎症和慢性疾病中的作用。
影响因子：
64.8
作者：
Handschin, Christoph;Spiegelman, Bruce M.
通讯作者：
Spiegelman, Bruce M.
影响因子：
29
作者：
Barres, Romain;Yan, Jie;Zierath, Juleen R.
通讯作者：
Zierath, Juleen R.
DOI：
10.1126/science.aaw2622
发表时间：
2020-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Horowitz AM;Fan X;Bieri G;Smith LK;Sanchez-Diaz CI;Schroer AB;Gontier G;Casaletto KB;Kramer JH;Williams KE;Villeda SA
通讯作者：
Villeda SA
影响因子：
56.9
作者：
Acosta-Rodriguez, Victoria;Rijo-Ferreira, Filipa;Izumo, Mariko;Xu, Pin;Wight-Carter, Mary;Green, Carla B.;Takahashi, Joseph S.
通讯作者：
Takahashi, Joseph S.