Role of the enteric microbiota in intestinal homeostasis and inflammation.
Role of the enteric microbiota in intestinal homeostasis and inflammation.
复制标题
肠性微生物群在肠内稳态和炎症中的作用。
DOI：
10.1016/j.freeradbiomed.2013.11.008
复制
发表时间：
2014-03
影响因子：
7.4
通讯作者：
Grisham, Matthew B.
中科院分区：
文献类型：
--
作者：
Koboziev, Iurii;Webb, Cynthia Reinoso;Furr, Kathryn L.;Grisham, Matthew B.
关键词：
哺乳动物的肠道比身体中的任何其他组织遇到更多的微生物，因此使其成为免疫系统中最大和最复杂的组成部分。事实上，在健康的人类肠道内有超过100万亿（1014）个微生物，其中来自这种多样化微生物组的基因总数超过整个人类基因组的至少100倍。我们与肠道微生物群的共存代表了一种动态和互利的关系，这种关系被认为是健康和疾病的主要决定因素。由于肠道微生物诱导局部和/或全身炎症的潜力，肠道免疫系统已经发展出许多免疫机制来保护宿主免受病原性感染，同时限制伴随这些免疫应答的炎性组织损伤。不能适当调节肠粘膜免疫被认为是在炎性肠病（IBD;克罗恩病，溃疡性结肠炎）中观察到的炎性组织损伤的原因。越来越多的实验和临床证据强烈表明，IBD是遗传易感个体对正常肠道植物群组分的免疫应答失调所致。本文综述了肠道菌群在肠道内环境稳定和慢性肠道炎症发病机制中的作用。
The mammalian intestine encounters many more microorganisms than any other tissue in the body thus making it the largest and most complex component of the immune system. Indeed, there are greater than 100 trillion (1014) microbes within the healthy human intestine where the total number of genes derived from this diverse microbiome exceeds that of the entire human genome by at least 100-fold. Our coexistence with the gut microbiota represents a dynamic and mutually beneficial relationship that is thought to be a major determinant of health and disease. Because of the potential for intestinal microorganisms to induce local and/or systemic inflammation, the intestinal immune system has developed a number of immune mechanisms to protect the host from pathogenic infections while limiting the inflammatory tissue injury that accompanies these immune responses. Failure to properly regulate intestinal mucosal immunity is thought to be responsible for the inflammatory tissue injury observed in the inflammatory bowel diseases (IBD; Crohn's disease, ulcerative colitis). An accumulating body of experimental and clinical evidence strongly suggest that IBD results from a dysregulated immune response to components of the normal gut flora in genetically-susceptible individuals. The objective of this review is to present our current understanding of the role that enteric microbiota play in intestinal homeostasis and pathogenesis of chronic intestinal inflammation.
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影响因子：
64.8
作者：
Devkota, Suzanne;Wang, Yunwei;Musch, Mark W.;Leone, Vanessa;Fehlner-Peach, Hannah;Nadimpalli, Anuradha;Antonopoulos, Dionysios A.;Jabri, Bana;Chang, Eugene B.
通讯作者：
Chang, Eugene B.
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
4.3
作者：
Fava, Francesca;Danese, Silvio
通讯作者：
Danese, Silvio
影响因子：
9.4
作者：
De La Cochetière, MF;Durand, T;Doré, J
通讯作者：
Doré, J
影响因子：
64.5
作者：
Chung H;Pamp SJ;Hill JA;Surana NK;Edelman SM;Troy EB;Reading NC;Villablanca EJ;Wang S;Mora JR;Umesaki Y;Mathis D;Benoist C;Relman DA;Kasper DL
通讯作者：
Kasper DL