A Cross-Sectional Serosurvey of Anti-Orthopoxvirus Antibodies in Central and Western Africa.
A Cross-Sectional Serosurvey of Anti-Orthopoxvirus Antibodies in Central and Western Africa.
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DOI：
10.3390/v9100278
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发表时间：
2017-09-29
期刊：
影响因子：
--
通讯作者：
Nitsche A
中科院分区：
文献类型：
--
作者：
Leendertz SAJ;Stern D;Theophil D;Anoh E;Mossoun A;Schubert G;Wiersma L;Akoua-Koffi C;Couacy-Hymann E;Muyembe-Tamfum JJ;Karhemere S;Pauly M;Schrick L;Leendertz FH;Nitsche A
自从根除天花和随后停止全球天花疫苗接种计划以来，除天花病毒外，其他正痘病毒日益对人类健康构成威胁。为了调查与正痘病毒自然接触的程度和这种接触可能的人口危险因素，我们在西非和中非进行了抗正痘病毒IgG抗体的横断面血清调查。为此，根据可能的天花疫苗接种情况，将居住在Côte科特迪瓦（CIV, n = 737）和刚果民主共和国（COD, n = 267）森林地区的人们分为不同的组。抗正痘病毒抗体的总体流行率在CIV为51%，在COD为60%。在接种疫苗的人群中，血清阳性率高（CIV为80%，COD为96%）表明疫苗接种后免疫反应持续时间长。在未接种疫苗的参与者中，19% （CIV）和26% （COD）的血清患病率表明经常接触正痘病毒。多因素logistic回归分析显示，接种部分人群COD抗体水平高于CIV抗体水平，且随年龄增长而升高，女性略高于男性。在未接种疫苗的人群中，这些因素都没有显著影响抗体水平。总之，我们的研究结果证实，在CIV和COD地区曾接种过天花疫苗的人群中，抗正痘病毒血清流行率出乎意料地高，但更出乎意料的是，这意味着西非和中非经常接触正痘病毒，即使在没有公认的疫情的情况下也是如此。
Since the eradication of smallpox and the subsequent discontinuation of the worldwide smallpox vaccination program, other Orthopoxviruses beside Variola virus have been increasingly representing a risk to human health. To investigate the extent of natural contact with Orthopoxviruses and possible demographic risk factors for such an exposure, we performed a cross-sectional serosurvey of anti-Orthopoxvirus IgG antibodies in West and Central Africa. To this end, people living in forest regions in Côte d’Ivoire (CIV, n = 737) and the Democratic Republic of the Congo (COD, n = 267) were assigned into groups according to their likely smallpox vaccination status. The overall prevalence of anti-Orthopoxvirus antibodies was 51% in CIV and 60% in COD. High rates of seropositivity among the vaccinated part of the population (80% in CIV; 96% COD) indicated a long-lasting post vaccination immune response. In non-vaccinated participants, seroprevalences of 19% (CIV) and 26% (COD) indicated regular contact with Orthopoxviruses. Multivariate logistic regression revealed that the antibody level in the vaccinated part of the population was higher in COD than in CIV, increased with age and was slightly higher in females than males. In the unvaccinated part of the population none of these factors influenced antibody level significantly. In conclusion, our results confirm expectedly high anti-Orthopoxvirus seroprevalences in previously smallpox-vaccinated people living in CIV and the COD but more unexpectedly imply regular contact with Orthopoxviruses both in Western and Central Africa, even in the absence of recognized outbreaks.
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影响因子：
3.8
作者：
Barr DJ
通讯作者：
Barr DJ
影响因子：
64.5
作者：
Gilchuk, Iuliia;Gilchuk, Pavlo;Sapparapu, Gopal;Lampley, Rebecca;Singh, Vidisha;Kose, Nurgun;Blum, David L.;Hughes, Laura J.;Satheshkumar, Panayampalli S.;Townsend, Michael B.;Kondas, Ashley V.;Reed, Zachary;Weiner, Zachary;Olson, Victoria A.;Hammarlund, Erika;Raue, Hans-Peter;Slifka, Mark K.;Slaughter, James C.;Graham, Barney S.;Edwards, Kathryn M.;Eisenberg, Roselyn J.;Cohen, Gary H.;Joyce, Sebastian;Crowe, James E., Jr.
通讯作者：
Crowe, James E., Jr.
影响因子：
4.4
作者：
Crotty, S;Felgner, P;Ahmed, R
通讯作者：
Ahmed, R
影响因子：
3.7
作者：
Levine RS;Peterson AT;Yorita KL;Carroll D;Damon IK;Reynolds MG
通讯作者：
Reynolds MG
DOI：
10.4269/ajtmh.2007.77.1150
发表时间：
2007-12-01
影响因子：
3.3
作者：
Lederman, Edith R.;Reynolds, Mary G.;Damon, Inger K.
通讯作者：
Damon, Inger K.