Genetic and environmental contributions to depression in Sri Lanka.
Genetic and environmental contributions to depression in Sri Lanka.
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DOI：
10.1192/bjp.bp.109.063529
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发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
Hotopf M
中科院分区：
文献类型：
--
作者：
Ball HA;Sumathipala A;Siribaddana SH;Kovas Y;Glozier N;McGuffin P;Hotopf M
背景在高收入的西方国家，抑郁症的易感性是由遗传和非家庭环境影响造成的。在不同的背景下，环境可能对人口发挥不同的作用。目的在低收入国家进行的第一项大型、基于人群的双生子研究中，检查抑郁症的遗传度。方法在斯里兰卡的3908对成年双胞胎中评估终身抑郁和更广泛的抑郁易感性（D-探针）测量（CoTASS研究）。结果D探针的广义定义存在性别差异，女性的遗传贡献率（61%）高于男性（4%）。抑郁症的结果相似，但患病率太低，无法估计男性的遗传力。结论：在斯里兰卡样本中，遗传因素对女性抑郁症的影响似乎至少与高收入国家一样强。结论对男性来说不太清楚，但表明环境而不是基因起着更大的作用。 环境影响的性质和程度也可能因人口而异。
Background Susceptibility to depression results from genetic and non-familially shared environmental influences in high-income, Western countries. Environments may play a different role for populations in different contexts. Aims To examine heritability of depression in the first large, population-based twin study in a low-income country. Method Lifetime depression and a broader measure of depression susceptibility (D-probe) were assessed in 3908 adult twins in Sri Lanka (the CoTASS study). Results There were gender differences for the broad definition (D-probe), with a higher genetic contribution in females (61%) than males (4%). Results were similar for depression, but the prevalence was too low to estimate heritability for males. Conclusions Genetic influences on depression in women appear to be at least as strong in this Sri Lankan sample as in higher-income countries. Conclusions are less clear for men but suggest a larger role for environments rather than genes. The nature as well as the magnitude of environmental influences may also differ across populations.
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