The influence of gene-environment interactions on the development of alcoholism and drug dependence.
The influence of gene-environment interactions on the development of alcoholism and drug dependence.
复制标题
DOI：
10.1007/s11920-011-0252-9
复制
发表时间：
2012-04
影响因子：
6.7
通讯作者：
Enoch, Mary-Anne
中科院分区：
文献类型：
--
作者：
Enoch, Mary-Anne
关键词：
Childhood maltreatmentSexual abusePhysical abuseGene-environment interactionsAlcoholismDrug dependenceStressful life eventsCrossover of riskDifferential susceptibility hypothesisAlcohol dependenceCocaine dependenceAdolescent problem drinkingHPA axisStress circuitryCortisolReward pathwayDopamineCorpus callosumSLC6A45-HTTLPRMAOA-LPRCRHBPCRHR1FKBP5GABRA2COMTPER1KCNJ6
酒精中毒和药物依赖是常见的精神疾病，遗传率约为50%，因此遗传和环境影响同样重要。早期生活压力是青少年问题饮酒/药物使用和成年后酒精/药物依赖的预测因子，但控制酒精/药物可用性的调节因素很重要。成瘾的风险-弹性平衡可能部分归因于遗传变异和环境压力（G×E）之间的相互作用;这已被推断遗传风险的双生子研究所证实。检测G×E效应的测量基因型研究使用了一系列酒精消费和诊断表型以及从早期到成年的过去一年生活事件的压力源。在这篇文章中，该领域的现状进行了批判性的审查，并提出了建议，为今后的研究。
Alcoholism and drug dependence are common psychiatric disorders with a heritability of about 50%; therefore genetic and environmental influences are equally important. Early-life stress is a predictor of adolescent problem drinking/drug use and alcohol/drug dependence in adulthood, but moderating factors governing the availability of alcohol/drug are important. The risk–resilience balance for addiction may be due in part to the interaction between genetic variation and environment stressors (G×E); this has been confirmed by twin studies of inferred genetic risk. Measured genotype studies to detect G×E effects have used a range of alcohol consumption and diagnostic phenotypes and stressors ranging from early-life to adulthood past year life events. In this article, the current state of the field is critically reviewed and suggestions are put forth for future research.
登录
查看更多内容
影响因子：
11
作者：
通讯作者：
--
影响因子：
2.6
作者：
Eaves, Lindon J.;Prom, Elizabeth C.;Silberg, Judy L.
通讯作者：
Silberg, Judy L.
影响因子：
7.6
作者：
Dube, S. R.;Miller, J. W.;Anda, R. F.
通讯作者：
Anda, R. F.
影响因子：
10.6
作者：
Covault, Jonathan;Tennen, Howard;Kranzler, Henry R.
通讯作者：
Kranzler, Henry R.
影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.