Unexpectedly higher levels of anti-orthopoxvirus neutralizing antibodies are observed among gay men than general adult population.
Unexpectedly higher levels of anti-orthopoxvirus neutralizing antibodies are observed among gay men than general adult population.
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DOI：
10.1186/s12916-023-02872-0
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发表时间：
2023-05-16
期刊：
影响因子：
9.3
通讯作者：
Wan, Yanmin
中科院分区：
文献类型：
--
作者：
Feng, Yanmeng;Zhang, Yifan;Liu, Shengya;Guo, Meng;Huang, Haojie;Guo, Cuiyuan;Wang, Wanhai;Zhang, Wenhong;Tang, Heng;Wan, Yanmin
当前猴痘疫情中的确诊病例主要是在男男性行为者（MSM）网络中发现的。预先存在的抗体可能会对猴痘病毒 (MPXV) 的传播产生深远的影响，但目前男同性恋者中 MPXV 抗体的流行情况尚不清楚。一组男同性恋者 (n = 326) 和一组普通成年人 (n = 295) 被纳入这项研究。测量了针对 MPXV/痘苗病毒的结合抗体反应和针对痘苗病毒（天坛株）的中和抗体反应。然后比较这两个队列的抗体反应，以及 1981 年之前和之后出生的个体的反应（当时中国停止天花疫苗接种）。最后，分别分析了 MSM 队列中抗 MPXV 抗体反应与抗牛痘抗体反应之间的相关性，以及先前存在的抗正痘病毒抗体反应与诊断出的性传播感染 (STI) 之间的关联。我们的数据显示，在1981年之前和之后出生的个体中都可以检测到针对MPXV H3、A29、A35、E8、B6、M1蛋白和痘苗全病毒裂解物的结合抗体，其中在一般人群队列中1981年之前出生的个体中抗痘苗结合抗体的流行率显着较高。此外，我们意外地发现，1981年及以后出生的MSM队列个体中针对MPXV H3、A29、A35、E8和M1蛋白的结合抗体反应的阳性率显着较低，但与一般人群队列中年龄匹配的参与者相比，这些个体中抗MPXV B6和抗牛痘中和抗体反应的阳性率显着较高。此外，我们证明，在一般人群队列中 1981 年之前出生的个体中，抗 MPXV 抗体反应的阳性率和阴性率与抗痘苗抗体反应相关，但在两个队列中 1981 年/之后出生的个体中没有观察到显着关联。 MSM 队列中患有和未诊断出性传播感染的个体之间的结合抗体反应和中和抗体反应的阳性率相当。在 MSM 队列和一般人群队列中可以轻松检测到抗 MPXV 和抗牛痘抗体。与一般人群队列中年龄匹配的个体相比，MSM 队列中未接种天花疫苗的个体中观察到更高水平的抗痘苗中和抗体反应。在线版本包含可在 10.1186/s12916-023-02872-0 获取的补充材料。
The confirmed cases in the current outbreak of Monkeypox are predominantly identified in the networks of men who have sex with men (MSM). The preexisting antibodies may profoundly impact the transmission of monkeypox virus (MPXV), however the current-day prevalence of antibodies against MPXV among gay men is not well characterized. A cohort of gay men (n = 326) and a cohort of the general adult population (n = 295) were enrolled in this study. Binding antibodies responses against MPXV/vaccinia and neutralizing antibody responses against vaccinia virus (Tiantan strain) were measured. The antibody responses of these two cohorts were then compared, as well as the responses of individuals born before and in/after 1981 (when the smallpox vaccination ceased in China). Finally, the correlation between the anti-MPXV antibody responses and the anti-vaccinia antibody responses, and the associations between preexisting anti-orthopoxvirus antibody responses and the diagnosed sexually transmitted infections (STIs) in the MSM cohort were analyzed separately. Our data showed that binding antibodies against MPXV H3, A29, A35, E8, B6, M1 proteins and vaccinia whole-virus lysate could be detected in individuals born both before and in/after 1981, of which the prevalence of anti-vaccinia binding antibodies was significantly higher among individuals born before 1981 in the general population cohort. Moreover, we unexpectedly found that the positive rates of binding antibody responses against MPXV H3, A29, A35, E8 and M1 proteins were significantly lower among individuals of the MSM cohort born in/after 1981, but the positive rates of anti-MPXV B6 and anti-vaccinia neutralizing antibody responses were significantly higher among these individuals compared to those of age-matched participants in the general population cohort. Additionally, we demonstrated that the positive and negative rates of anti-MPXV antibody responses were associated with the anti-vaccinia antibody responses among individuals born before 1981 in the general population cohort, but no significant association was observed among individuals born in/after 1981 in both cohorts. The positive rates of both the binding and the neutralizing antibody responses were comparable between individuals with and without diagnosed STIs in the MSM cohort. Anti-MPXV and anti-vaccinia antibodies could be readily detected in an MSM cohort and a general population cohort. And a higher level of anti-vaccinia neutralizing antibody responses was observed among individuals who did not get vaccinated against smallpox in the MSM cohort compared to age-matched individuals in the general population cohort. The online version contains supplementary material available at 10.1186/s12916-023-02872-0.
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影响因子：
82.9
作者：
Isidro, Joana;Borges, Vitor;Pinto, Miguel;Sobral, Daniel;Santos, Joao Dourado;Nunes, Alexandra;Mixao, Veronica;Ferreira, Rita;Santos, Daniela;Duarte, Silvia;Vieira, Luis;Borrego, Maria Jose;Nuncio, Sofia;de Carvalho, Isabel Lopes;Pelerito, Ana;Cordeiro, Rita;Gomes, Joao Paulo
通讯作者：
Gomes, Joao Paulo
DOI：
10.2807/1560-7917.es.2022.27.22.2200424
发表时间：
2022-06
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
通讯作者：
--
影响因子：
7.5
作者：
Noe, Sebastian;Zange, Sabine;Seilmaier, Michael;Antwerpen, Markus H.;Fenzl, Thomas;Schneider, Jochen;Spinner, Christoph D.;Bugert, Joachim J.;Wendtner, Clemens-Martin;Woelfel, Roman
通讯作者：
Woelfel, Roman
影响因子：
11.8
作者：
Nguyen PY;Ajisegiri WS;Costantino V;Chughtai AA;MacIntyre CR
通讯作者：
MacIntyre CR
影响因子：
5.4
作者：
Kaever, Thomas;Meng, Xiangzhi;Xiang, Yan
通讯作者：
Xiang, Yan