Noninvasive remote activation of the ventral midbrain by transcranial direct current stimulation of prefrontal cortex.
Noninvasive remote activation of the ventral midbrain by transcranial direct current stimulation of prefrontal cortex.
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DOI：
10.1038/tp.2013.44
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发表时间：
2013-06-11
影响因子：
6.8
通讯作者：
Shimojo S
中科院分区：
文献类型：
--
作者：
Chib VS;Yun K;Takahashi H;Shimojo S
中脑位于大脑深处，在奖赏、动机、运动和各种神经精神疾病如帕金森病、精神分裂症、抑郁症和成瘾的病理生理学中起重要作用。迄今为止，作用于该区域的主要手段是药物干预或植入电极。在这里，我们介绍了一种新的非侵入性脑刺激技术，利用中脑和前额皮质的高度互连的性质来刺激大脑深部区域。使用经颅直流电刺激（tDCS）的前额叶皮层，我们能够远程激活相互连接的中脑，并导致参与者对面部吸引力的评价增加。在刺激后，前额叶/中脑连接增强的参与者在吸引力评分上表现出更大的增长。这些结果表明，非侵入性的直接刺激前额叶皮层可以诱导远端连接的中脑的神经活动，这直接影响行为。此外，这些结果表明，这种tDCS协议可以提供一个有前途的方法来调节中脑功能，在神经精神疾病中断。
The midbrain lies deep within the brain and has an important role in reward, motivation, movement and the pathophysiology of various neuropsychiatric disorders such as Parkinson's disease, schizophrenia, depression and addiction. To date, the primary means of acting on this region has been with pharmacological interventions or implanted electrodes. Here we introduce a new noninvasive brain stimulation technique that exploits the highly interconnected nature of the midbrain and prefrontal cortex to stimulate deep brain regions. Using transcranial direct current stimulation (tDCS) of the prefrontal cortex, we were able to remotely activate the interconnected midbrain and cause increases in participants' appraisals of facial attractiveness. Participants with more enhanced prefrontal/midbrain connectivity following stimulation exhibited greater increases in attractiveness ratings. These results illustrate that noninvasive direct stimulation of prefrontal cortex can induce neural activity in the distally connected midbrain, which directly effects behavior. Furthermore, these results suggest that this tDCS protocol could provide a promising approach to modulate midbrain functions that are disrupted in neuropsychiatric disorders.
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影响因子：
56.9
作者：
Hare, Todd A.;Camerer, Colin F.;Rangel, Antonio
通讯作者：
Rangel, Antonio
DOI：
10.1007/bf02190342
发表时间：
1992-09-01
影响因子：
4.7
作者：
GAEBEL, W;WOLWER, W
通讯作者：
WOLWER, W
DOI：
10.1523/jneurosci.0895-11.2011
发表时间：
2011-07-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ballard IC;Murty VP;Carter RM;MacInnes JJ;Huettel SA;Adcock RA
通讯作者：
Adcock RA
影响因子：
11
作者：
Boggio, P. S.;Khoury, L. P.;Fregni, F.
通讯作者：
Fregni, F.
影响因子：
5.7
作者：
Deichmann, R;Gottfried, JA;Turner, R
通讯作者：
Turner, R