Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins.
Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins.
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DOI：
10.1016/j.preteyeres.2009.08.001
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发表时间：
2009-11
影响因子：
17.8
通讯作者：
Rudolf, Martin
中科院分区：
文献类型：
--
作者：
Curcio, Christine A.;Johnson, Mark;Huang, Jiahn-Dar;Rudolf, Martin
关键词：
年龄相关性黄斑变性（ARMD）的最大危险因素是高龄。人类视网膜中一个突出的与年龄相关的变化是在整个成年期正常布鲁氏膜（BrM）中组织化学可检测的中性脂质的积累。这种变化有可能对视网膜色素上皮（RPE）的生理产生重大影响。它与基底线状沉积物（ARMD的特征性细胞外含脂病变）发生在同一腔室。在这里，我们从光镜组织化学、超微结构、组织脂质谱和分离脂蛋白以及基因表达分析中提出证据，表明这种沉积可以由富含胆固醇的酯化、含载脂蛋白b的脂蛋白颗粒组成的RPE产生。这些工作使得ARMD病变形成及其后果被概念化为对亚内皮载脂蛋白B脂蛋白保留的反应，类似于广泛接受的动脉粥样硬化性冠状动脉疾病（CAD）模型。这种方法提供了广泛的知识基础和复杂的临床装备，可以很容易地用于开发新的模型系统和ARMD患者的未来利益。
The largest risk factor for age-related macular degeneration (ARMD) is advanced age. A prominent age-related change in the human retina is the accumulation of histochemically detectable neutral lipid in normal Bruch’s membrane (BrM) throughout adulthood. This change has the potential to have a major impact on physiology of the retinal pigment epithelium (RPE). It occurs in the same compartment as drusen and basal linear deposit, the pathognomonic extracellular, lipid-containing lesions of ARMD. Here we present evidence from light microscopic histochemistry, ultrastructure, lipid profiling of tissues and isolated lipoproteins, and gene expression analysis that this deposition can be accounted for by esterified cholesterol-rich, apolipoprotein B-containing lipoprotein particles constitutively produced by the RPE. This work collectively allows ARMD lesion formation and its aftermath to be conceptualized as a response to the retention of a sub-endothelial apolipoprotein B lipoprotein, similar to a widely accepted model of atherosclerotic coronary artery disease (CAD). This approach provides a wide knowledge base and sophisticated clinical armamentarium that can be readily exploited for the development of new model systems and the future benefit of ARMD patients.
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影响因子：
4.8
作者：
Björkegren, J;Véniant, M;Young, SG
通讯作者：
Young, SG
影响因子：
5.3
作者：
BALL, RY;STOWERS, EC;MITCHINSON, MJ
通讯作者：
MITCHINSON, MJ
影响因子：
3.4
作者：
Bretillon, Lionel;Thuret, Gilles;Creuzot-Garcher, Catherine P.
通讯作者：
Creuzot-Garcher, Catherine P.
影响因子：
3.4
作者：
Anderson, DH;Talaga, KC;Johnson, LV
通讯作者：
Johnson, LV
DOI：
10.1097/00006982-199414020-00006
发表时间：
1994-01-01
影响因子：
3.3
作者：
BRESSLER, NM;SILVA, JC;GREEN, WR
通讯作者：
GREEN, WR