Dopamine regulates intrinsic excitability thereby gating successful induction of spike timing-dependent plasticity in CA1 of the hippocampus.
Dopamine regulates intrinsic excitability thereby gating successful induction of spike timing-dependent plasticity in CA1 of the hippocampus.
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DOI：
10.3389/fnins.2013.00025
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发表时间：
2013
影响因子：
4.3
通讯作者：
Lessmann V
中科院分区：
文献类型：
--
作者：
Edelmann E;Lessmann V
长时程增强（LTP）和长时程抑制（LTD）通常被认为是与学习和记忆相关的细胞。不同类型的LTP诱导方案不同的刺激的严重程度可以区分在海马CA 1区。为了更好地理解信号传导机制和神经调质如多巴胺（DA）在突触可塑性中的参与，应使用较不严重和更生理性的低频诱导方案。本文综述了海马CA 3-CA 1区突触发放电位时间依赖性可塑性（STDP）的关键决定因素。我们发现，DA通过D1受体信号传导，而不是由β-肾上腺素能激动剂异丙肾上腺素激活的肾上腺素能信号传导，对于STDP在CA 3-CA 1突触的成功表达是重要的。DA对STDP的影响是由尖峰放电特性的变化引起的，从而改变了突触后CA 1神经元的内在兴奋性，并门控STDP。尽管β-肾上腺素能信号传导也导致类似（但不相同）的放电模式调节，但它不会使STDP成为可能。在这集中的审查，我们将讨论目前的文献多巴胺能调制的LTP在CA 1，特别关注时间依赖性（t-）LTP，我们将提出可能的原因STDP DA选择性门控[而不是去甲肾上腺素（NA）]在CA 1。
Long-term potentiation (LTP) and long-term depression (LTD) are generally assumed to be cellular correlates for learning and memory. Different types of LTP induction protocols differing in severity of stimulation can be distinguished in CA1 of the hippocampus. To better understand signaling mechanisms and involvement of neuromodulators such as dopamine (DA) in synaptic plasticity, less severe and more physiological low frequency induction protocols should be used. In the study which is reviewed here, critical determinants of spike timing-dependent plasticity (STDP) at hippocampal CA3-CA1 synapses were investigated. We found that DA via D1 receptor signaling, but not adrenergic signaling activated by the β-adrenergic agonist isoproterenol, is important for successful expression of STDP at CA3-CA1 synapses. The DA effect on STDP is paralleled by changes in spike firing properties, thereby changing intrinsic excitability of postsynaptic CA1 neurons, and gating STDP. Whereas β-adrenergic signaling also leads to a similar (but not identical) regulation of firing pattern, it does not enable STDP. In this focused review we will discuss the current literature on dopaminergic modulation of LTP in CA1, with a special focus on timing dependent (t-)LTP, and we will suggest possible reasons for the selective gating of STDP by DA [but not noradrenaline (NA)] in CA1.
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影响因子：
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作者：
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通讯作者：
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