The Genome 10K Project: a way forward.

The Genome 10K Project: a way forward.
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DOI:
10.1146/annurev-animal-090414-014900
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发表时间:
2015
影响因子:
12
通讯作者:
O'Brien SJ
O'Brien SJ
中科院分区:
农林科学1区
文献类型:
--
作者:
Koepfli KP;Paten B;Genome 10K Community of Scientists;O'Brien SJ

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Genome 10K 计划由生物学家和基因组科学家组成的联盟于 2009 年建立,致力于促进 10,000 个脊椎动物物种的完整基因组的测序和分析。从那时起,选定和启动的物种数量已从约 26 个增加到 277 个已测序或正在资助中的物种,五年内增加了约十倍。在此,我们总结了 2014 年中期所取得的进展和承诺,并概述了实现 10,000 个物种目标所取得的成就和面临的挑战。我们总结了已知脊椎动物基因组项目的状况,推荐了宣布基因组已测序或已完成的标准,并提供了我们对 Genome 10K 前景的当前和未来愿景。这项努力雄心勃勃、大胆、昂贵且不确定,但 Genome 10K 科学家联盟和全球基因组学界正在共同朝着他们的目标迈进,即为下一代提供为许多脊椎动物物种提供基因组赋权的礼物。
The Genome 10K Project was established in 2009 by a consortium of biologists and genome scientists determined to facilitate the sequencing and analysis of the complete genomes of 10,000 vertebrate species. Since then the number of selected and initiated species has risen from ~26 to 277 sequenced or ongoing with funding, an approximately tenfold increase in five years. Here we summarize the advances and commitments that have occurred by mid-2014 and outline the achievements and present challenges of reaching the 10,000-species goal. We summarize the status of known vertebrate genome projects, recommend standards for pronouncing a genome as sequenced or completed, and provide our present and future vision of the landscape of Genome 10K. The endeavor is ambitious, bold, expensive, and uncertain, but together the Genome 10K Consortium of Scientists and the worldwide genomics community are moving toward their goal of delivering to the coming generation the gift of genome empowerment for many vertebrate species.
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