Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions.
Zonula occludens-1 and -2 are cytosolic scaffolds that regulate the assembly of cellular junctions.
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DOI：
10.1111/j.1749-6632.2009.04440.x
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发表时间：
2009-05
影响因子：
5.2
通讯作者：
Anderson JM
中科院分区：
文献类型：
--
作者：
Fanning AS;Anderson JM
上皮细胞和内皮细胞紧密连接屏障的完整性对人类健康至关重要，但我们仍然缺乏关于屏障在发育过程中如何形成或对病理学和药理学损伤作出反应的详细机制知识。这限制了我们对疾病中屏障功能障碍的理解，并减缓了治疗策略的发展。最近的研究证实了一个长期存在但以前没有得到支持的观点，即封闭小带（ZO）蛋白ZO-1和ZO-2是屏障形成的关键决定因素。然而，ZO蛋白也可以是粘附连接的组成部分，最近的研究表明，ZO蛋白也可能促进这些连接在上皮形态发生过程中的组装和功能。我们回顾这些研究，并概述了最近的几个观察表明，ZO蛋白的作用之一是调节细胞骨架的动态在细胞连接。最后，我们提出了一个模型，通过该模型，ZO蛋白在粘附连接和紧密连接中的功能活动由一种新的调节基序（称为U6或酸性基序）区分。
The integrity of the tight junction barrier in epithelial and endothelial cells is critical to human health, but we still lack a detailed mechanistic knowledge of how the barrier is formed during development or responds to pathological and pharmacological insults. This limits our understanding of barrier dysfunction in disease and slows the development of therapeutic strategies. Recent studies confirm the long-maintained but previously unsupported view that the zonula occludens (ZO) proteins ZO-1 and ZO-2 are critical determinants of barrier formation. However, ZO proteins can also be components of adherens junctions, and recent studies suggest that ZO proteins may also promote the assembly and function of these junctions during epithelial morphogenesis. We review these studies and outline several recent observations that suggest that one role of ZO proteins is to regulate cytoskeletal dynamics at cell junctions. Finally, we propose a model by which the functional activities of ZO proteins in the adherens junction and tight junction are differentiated by a novel regulatory motif known as the U6 or acidic motif.
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三个紧密连接相关的Maguks ZO-1，ZO-2和ZO-3与Claudins的Cooh Termini直接结合。
DOI：
10.1083/jcb.147.6.1351
发表时间：
1999-12-13
期刊：
The Journal of cell biology
影响因子：
--
作者：
Itoh M;Furuse M;Morita K;Kubota K;Saitou M;Tsukita S
通讯作者：
Tsukita S
DOI：
10.1083/jcb.200612080
发表时间：
2007-03-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ikenouchi J;Umeda K;Tsukita S;Furuse M;Tsukita S
通讯作者：
Tsukita S
影响因子：
3.3
作者：
Kausalya, PJ;Phua, DCY;Hunziker, W
通讯作者：
Hunziker, W
影响因子：
3.3
作者：
Katsuno, Tatsuya;Umeda, Kazuaki;Tsukita, Sachiko
通讯作者：
Tsukita, Sachiko
Afadin：一种新型的肌动蛋白结合蛋白，其中一个PDZ结构域位于基于钙粘蛋白的细胞到细胞粘附连接处。
影响因子：
7.8
作者：
Mandai, K;Nakanishi, H;Satoh, A;Obaishi, H;Wada, M;Nishioka, H;Itoh, M;Mizoguchi, A;Aoki, T;Fujimoto, T;Matsuda, Y;Tsukita, S;Takai, Y
通讯作者：
Takai, Y