Pregnancy and Infant Development (PRIDE)-a preliminary observational study of maternal adversity and infant development.
Pregnancy and Infant Development (PRIDE)-a preliminary observational study of maternal adversity and infant development.
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DOI：
10.1186/s12887-021-02801-1
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发表时间：
2021-10-15
期刊：
影响因子：
2.4
通讯作者：
Folger A
中科院分区：
文献类型：
--
作者：
Bowers K;Ding L;Yolton K;Ji H;Nidey N;Meyer J;Ammerman RT;Van Ginkel J;Folger A
来自社会经济弱势家庭的儿童认知和社会情感发展受损的风险明显增加。处于贫困中的儿童有很高的发育迟缓风险。贫穷使人们不成比例地遭受心理逆境，这可能会损害后代的发展;然而，社会支持和复原力的其他方面可能会减轻这种影响。我们的目的是确定母亲的压力，逆境和社会支持与早期婴儿的神经行为和儿童行为在2年和3年之间的关联。我们在俄亥俄州的辛辛那提进行了一项纵向母婴队列研究。四个家庭研究访问完成，以收集母亲的压力，逆境和社会支持和婴儿和儿童的行为措施。婴儿神经行为（“高觉醒”婴儿）的测量结果来自1个月时的NICU网络神经行为量表（NNNS），并通过24个月和36个月时的儿童行为检查表（CBCL）测量外在和内在症状。线性和逻辑回归确定产妇的风险/保护因素和婴儿和儿童的行为措施之间的关联。我们使用分层和乘法交互作用的条款，以检查潜在的相互作用。我们招募了n = 55名孕妇，并在1个月时随访了53对母子，24个月时随访了40对母子，36个月时随访了27对母子。母亲的逆境和保护因素与一个月的神经行为无关。然而，母亲的抑郁和痛苦的措施，在怀孕显着相关的内在和外在的症状在24个月和36个月。这项试点研究确立了在社区干预计划中进行纵向研究的可行性。此外，虽然没有统计学显着的孕妇心理社会因素之间的关联在怀孕和婴儿的神经行为，有几个协会在24个月，主要是内化症状，持续到36个月。未来的工作将在一个更大的研究中复制发现，并探索这些协会的调解人和修改器。
Children from socioeconomically disadvantaged families have a markedly elevated risk for impaired cognitive and social-emotional development. Children in poverty experience have a high risk for developmental delays. Poverty engenders disproportionate exposure to psychological adversity which may contribute to impaired offspring development; however the effect may be mitigated by social support and other aspects of resilience. Our objective was to determine the association between maternal stress, adversity and social support and early infant neurobehavior and child behavior at two and three years. We conducted a longitudinal mother-infant cohort study nested within a regional home visiting program in Cincinnati, Ohio. Four home study visits were completed to collect measures of maternal stress, adversity and social support and infant and child behavior. A measure of infant neurobehavior (‘high-arousal’ infant) was derived from the NICU Network Neurobehavioral Scale (NNNS) at 1 month and externalizing and internalizing symptoms were measured by the Child Behavior Checklist (CBCL) at 24 and 36 months. Linear and logistic regression identified associations between maternal risk/protective factors and infant and child behavioral measures. We used stratification and multiplicative interaction terms to examine potential interactions. We enrolled n = 55 pregnant mothers and follow 53 mother–offspring dyads at 1 month, 40 dyads at 24 months and 27 dyads at 36 months. Maternal adversity and protective factors were not associated with neurobehavior at one month. However, maternal depression and measures of distress in pregnancy were significantly associated with internalizing and externalizing symptoms at 24 and 36 months. This pilot study established the feasibility of conducting longitudinal research within a community intervention program. In addition, although there were no statistically significant associations between maternal psychosocial factors in pregnancy and infant neurobehavior, there were several associations at 24 months, primarily internalizing symptoms, which persisted through 36 months. Future work will replicate findings within a larger study as well as explore mediators and modifiers of these associations.
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早期生活节目和神经发育障碍。
影响因子：
10.6
作者：
Bale, Tracy L.;Baram, Tallie Z.;Brown, Alan S.;Goldstein, Jill M.;Insel, Thomas R.;McCarthy, Margaret M.;Nemeroff, Charles B.;Reyes, Teresa M.;Simerly, Richard B.;Susser, Ezra S.;Nestler, Eric J.
通讯作者：
Nestler, Eric J.
影响因子：
6.3
作者：
Simon, Alan E.;Pastor, Patricia N.;Blumberg, Stephen J.
通讯作者：
Blumberg, Stephen J.
影响因子：
5.1
作者：
Steele, Emily;Wong, Evelyn;Waters, Elizabeth
通讯作者：
Waters, Elizabeth
影响因子：
8
作者：
Rosenberg, Steven A.;Zhang, Duan;Robinson, Cordelia C.
通讯作者：
Robinson, Cordelia C.
DOI：
10.1080/01674820802546220
发表时间：
2008-12
期刊：
Journal of psychosomatic obstetrics and gynaecology
影响因子：
--
作者：
DiPietro JA;Christensen AL;Costigan KA
通讯作者：
Costigan KA