Perinatal risk factors for diabetes in later life.
Perinatal risk factors for diabetes in later life.
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DOI：
10.2337/db08-0558
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发表时间：
2009-03
期刊：
影响因子：
7.7
通讯作者：
Ekbom, Anders
中科院分区：
文献类型：
--
作者：
Kaijser, Magnus;Bonamy, Anna-Karin Edstedt;Akre, Olof;Cnattingius, Sven;Granath, Fredrik;Norman, Mikael;Ekbom, Anders
低出生体重一直与成年后2型糖尿病风险增加相关，但胎儿生长不良和早产的个体贡献尚不清楚。因此，我们分别研究了这两个因素的重要性。研究设计和方法-我们确定了一组早产或低出生体重的受试者，从1925年到1949年在瑞典的四个主要分娩单位。从相同来源人群中确定了受试者的比较队列。在所有6，425名受试者中，2，931名出生时妊娠<37周，2，176名出生体重<2，500 g。通过1987年至2006年的全国医院登记，评估了参与者的疾病发生率。在随访期间，有508例糖尿病患者。低出生体重与糖尿病风险呈显著负相关（趋势P <0.0001）。妊娠期短和胎儿生长不良均与晚期糖尿病相关（趋势P值分别<0.0001和<0.0004）。与足月分娩相比，极早产（出生时妊娠≤32周）的风险比（HR）为1.67（95% CI 1.33-2.11）。出生体重低于胎龄平均出生体重的2个SD，与平均体重和高于平均值1个SD时的出生体重相比，HR为1.76（1.30-2.38）。结论：我们的研究结果表明，低出生体重和糖尿病之间的联系是由于与胎儿生长不良和胎龄短有关的因素。
OBJECTIVE—Low birth weight is consistently associated with an increased risk of type 2 diabetes in adulthood, but the individual contributions from poor fetal growth and preterm birth are not known. We therefore investigated the significance of these two factors separately. RESEARCH DESIGN AND METHODS—We identified a cohort of subjects born preterm or with low birth weight at term at four major delivery units in Sweden from 1925 through 1949. A comparison cohort of subjects was identified from the same source population. Of 6,425 subjects in all, 2,931 were born at <37 weeks of gestation and 2,176 had a birth weight <2,500 g. Disease occurrence among participants was assessed through nationwide hospital registers from 1987 through 2006. RESULTS—During follow-up, there were 508 cases of diabetes. Low birth weight was strongly negatively associated with risk of diabetes (P for trend <0.0001). Both short gestational duration and poor fetal growth were associated with later diabetes (P for trend <0.0001 and <0.0004, respectively). Very preterm birth (≤32 weeks of gestation at birth) was associated with a hazard ratio (HR) of 1.67 (95% CI 1.33–2.11) compared with term birth. Birth weights below 2 SDs of mean birth weight for gestational age were associated with an HR of 1.76 (1.30–2.38) compared with birth weights between the mean weight and the weight at 1 SD above the mean. CONCLUSIONS—Our results suggest that the association between low birth weight and diabetes is due to factors associated with both poor fetal growth and short gestational age.
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影响因子：
16.2
作者：
Wei, JN;Sung, FC;Chuang, LM
通讯作者：
Chuang, LM
影响因子：
--
作者：
MCCANCE, DR;PETTITT, DJ;BENNETT, PH
通讯作者：
BENNETT, PH
影响因子：
7.7
作者：
Barker, DJP;Eriksson, JG;Osmond, C
通讯作者：
Osmond, C
影响因子：
37.8
作者：
Kaijser, Magnus;Bonamy, Anna-Karin Edstedt;Ekbom, Anders
通讯作者：
Ekbom, Anders
影响因子：
158.5
作者：
Hovi, Petteri;Andersson, Sture;Kajantie, Eero
通讯作者：
Kajantie, Eero