The diagnostic value of 124I-PET in patients with differentiated thyroid cancer.
The diagnostic value of 124I-PET in patients with differentiated thyroid cancer.
复制标题
在分化甲状腺癌患者中，124i-PET的诊断值。
DOI：
10.1007/s00259-007-0660-6
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发表时间：
2008-05
影响因子：
9.1
通讯作者：
Links, Thera P.
中科院分区：
文献类型：
--
作者：
Phan, Ha T. T.;Jager, Pieter L.;Paans, Anne M. J.;Plukker, John T. M.;Sturkenboom, M. G. G.;Sluiter, W. J.;Wolffenbuttel, Bruce H. R.;Dierckx, Rudi A. J. O.;Links, Thera P.
本研究旨在评价~(124)I正电子发射断层扫描(PET)对晚期分化型甲状腺癌(DTC)的临床诊断价值，并与~(131)I全身扫描(WBS)结果进行比较。20例经组织学证实的晚期DTC患者(包括T4、结外肿瘤生长或远处转移)在消融4个月后接受了诊断性131I-WBS、124I-PET扫描和治疗后的131I-WBS。124I-PET的结果与诊断和治疗后的131I-WBS的结果进行了比较，并与放射学和/或细胞学检查结果进行了对照。124I-PET与诊断131I-WBS的比较。11例患者在~(124)I-PET上显示摄取。在这11例患者中，只有3例在诊断性131I扫描上也显示了摄取，但在124I-PET上摄取更清楚，异常更广泛。124I-PET与治疗后131I-WBS的比较。11名患者在124I-PET上显示摄取，9名患者在治疗后扫描中也可见摄取；另外2名患者在治疗后扫描中未观察到摄取，也无法证实解剖定位。两名患者在治疗后扫描上仅显示摄取，而在124I-PET上没有摄取：一名患者的摄取经MRI证实，另一名患者未发现解剖定位。在7名患者中，在两次扫描中都没有发现摄取。与低剂量诊断性131I扫描相比，124I-PET被证明是一种更好的诊断工具，并充分预测了随后的高剂量治疗后131I扫描的结果。
The purpose of this prospective study was to evaluate the clinical diagnostic value of iodine-124 (124I)-positron emission tomography (PET) in patients with advanced differentiated thyroid carcinoma (DTC) and to compare the 124I-PET imaging results with the 131I whole-body scan (WBS). Twenty patients with histologically proven advanced DTC (including T4, extra-nodal tumour growth, or distant metastases) underwent diagnostic 131I-WBS, 124I-PET scan, and post-treatment 131I-WBS 4 months after ablation. The findings on the 124I-PET were compared with the findings on the diagnostic and post-therapeutic 131I-WBS and were also correlated with radiologic and/or cytological investigations. 124 I-PET vs diagnostic 131 I-WBS. Eleven patients showed uptake on the 124I-PET. Only 3 of these 11 patients also showed uptake on the diagnostic 131I scan, but the uptake was more clearly visible and the abnormalities were more extensive on the 124I-PET. 124 I-PET vs post-treatment 131 I-WBS. Eleven patients showed uptake on the 124I-PET, which was also visible on the post-treatment scan in nine patients; in the other two patients, no uptake was observed on the post-treatment scan and no anatomical localisation could be confirmed. Two patients showed only uptake on the post-treatment scan without uptake on the 124I-PET: in one, the uptake was confirmed by MRI, and in the other, no anatomical localisation was found. In seven patients, no uptake was observed on both the scans. 124I-PET proved to be a superior diagnostic tool as compared to low-dose diagnostic 131I scans and adequately predicted findings on subsequent high-dose post-treatment 131I scans.
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DOI：
10.1007/s002590050176
发表时间：
1997-12-01
期刊：
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
影响因子：
--
作者：
Crawford, DC;Flower, MA;Harmer, CL
通讯作者：
Harmer, CL
影响因子：
5.8
作者：
FREY, P;TOWNSEND, D;DONATH, A
通讯作者：
DONATH, A
影响因子：
2.6
作者：
OTT, RJ;BATTY, V;SMITH, A
通讯作者：
SMITH, A
影响因子：
5.8
作者：
Baudin, E;Do Cao, C;Schlumberger, M
通讯作者：
Schlumberger, M
影响因子：
6.6
作者：
PARK, HM;PERKINS, OW;MANATUNGA, A
通讯作者：
MANATUNGA, A