Network analysis suggests a potentially 'evil' alliance of opportunistic pathogens inhibited by a cooperative network in human milk bacterial communities.
Network analysis suggests a potentially 'evil' alliance of opportunistic pathogens inhibited by a cooperative network in human milk bacterial communities.
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DOI：
10.1038/srep08275
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发表时间：
2015-02-05
影响因子：
4.6
通讯作者：
Forney LJ
中科院分区：
文献类型：
--
作者：
Sam Ma Z;Guan Q;Ye C;Zhang C;Foster JA;Forney LJ
母乳对于婴儿乃至人类文明的至关重要性已广为人知。然而，我们对牛奶微生物组的理解仅限于 OTU 编目和群落多样性计算。据我们所知，目前还没有关于牛奶微生物群内细菌相互作用的报道。为了弥补这一差距，我们基于 Hunt 等人重建了牛奶细菌群落网络。我们的分析表明，牛奶微生物组网络由两个互不相连的子网络组成。一个子网络是一个完全连接的完整图，由七个属作为节点组成，并且细菌之间的所有成对相互作用都是促进或合作的。相比之下，另一个由八个节点组成的子网络中的交互是混合的，但主要是合作的。有点令人惊讶的是，第二个子网络中唯一的“非合作”节点是相互合作的葡萄球菌和棒状杆菌，其中包括一些机会性病原体。葡萄球菌和棒状杆菌之间这种潜在的“邪恶”联盟可能会被第二个子网络中相互合作的剩余节点所抑制。我们假设“邪恶”联盟和“良性”联盟之间的“对抗”以及它们之间平衡的变化可能是导致乳腺炎的乳汁微生物群失调的原因。
The critical importance of human milk to infants and even human civilization has been well established. Yet our understanding of the milk microbiome has been limited to cataloguing OTUs and computation of community diversity. To the best of our knowledge, there has been no report on the bacterial interactions within the milk microbiome. To bridge this gap, we reconstructed a milk bacterial community network based on Hunt et al. Our analysis revealed that the milk microbiome network consists of two disconnected sub-networks. One sub-network is a fully connected complete graph consisting of seven genera as nodes and all of its pair-wise interactions among the bacteria are facilitative or cooperative. In contrast, the interactions in the other sub-network of eight nodes are mixed but dominantly cooperative. Somewhat surprisingly, the only ‘non-cooperative' nodes in the second sub-network are mutually cooperative Staphylococcus and Corynebacterium that include some opportunistic pathogens. This potentially ‘evil' alliance between Staphylococcus and Corynebacterium could be inhibited by the remaining nodes that cooperate with one another in the second sub-network. We postulate that the ‘confrontation' between the ‘evil' alliance and ‘benign' alliance and the shifting balance between them may be responsible for dysbiosis of the milk microbiome that permits mastitis.
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影响因子：
3
作者：
Kuchaiev O;Stevanović A;Hayes W;Pržulj N
通讯作者：
Pržulj N
DOI：
10.1126/science.1224203
发表时间：
2012-06-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Costello EK;Stagaman K;Dethlefsen L;Bohannan BJ;Relman DA
通讯作者：
Relman DA
影响因子：
5.4
作者：
Jeurink, P. V.;van Bergenhenegouwen, J.;Martin, R.
通讯作者：
Martin, R.
影响因子：
4.3
作者：
Faust K;Sathirapongsasuti JF;Izard J;Segata N;Gevers D;Raes J;Huttenhower C
通讯作者：
Huttenhower C
DOI：
10.1111/j.1574-695x.1999.tb01326.x
发表时间：
1999-08-01
影响因子：
--
作者：
Blackwell, CC;MacKenzie, DAC;Busuttil, A
通讯作者：
Busuttil, A