Cross-kingdom interaction between Candida albicans and oral bacteria.
Cross-kingdom interaction between Candida albicans and oral bacteria.
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DOI：
10.3389/fmicb.2022.911623
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发表时间：
2022
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
白色念珠菌是一种共生真菌，通常在口腔粘膜表面定植，主要影响免疫功能低下的个体。C.白色念珠菌和口腔微生物影响生物膜的细胞和生物化学组成，有助于改变生物膜相关口腔疾病的临床相关结果，例如发病机制、毒力和耐药性。值得注意的是，C.白色念珠菌和口腔细菌在龋齿、口腔粘膜炎、牙髓病和牙周病、与植入物相关的感染和口腔癌中已有充分的记载。C.白色念珠菌通过物理附着、细胞外信号和代谢交叉喂养与共存的口腔细菌相互作用。本文综述了近年来C.白念珠菌和不同的口腔细菌，特别侧重于潜在的机制及其与口腔疾病的发展和临床管理的相关性。
Candida albicans is a symbiotic fungus that commonly colonizes on oral mucosal surfaces and mainly affects immuno-compromised individuals. Polymicrobial interactions between C. albicans and oral microbes influence the cellular and biochemical composition of the biofilm, contributing to change clinically relevant outcomes of biofilm-related oral diseases, such as pathogenesis, virulence, and drug-resistance. Notably, the symbiotic relationships between C. albicans and oral bacteria have been well-documented in dental caries, oral mucositis, endodontic and periodontal diseases, implant-related infections, and oral cancer. C. albicans interacts with co-existing oral bacteria through physical attachment, extracellular signals, and metabolic cross-feeding. This review discusses the bacterial–fungal interactions between C. albicans and different oral bacteria, with a particular focus on the underlying mechanism and its relevance to the development and clinical management of oral diseases.
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影响因子：
3.6
作者：
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通讯作者：
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