Extracellular dopamine and norepinephrine in the developing rat prefrontal cortex: transient effects of early partial loss of dopamine.
Extracellular dopamine and norepinephrine in the developing rat prefrontal cortex: transient effects of early partial loss of dopamine.
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DOI：
10.1016/j.brainresbull.2009.01.012
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发表时间：
2009-04-29
影响因子：
3.8
通讯作者：
Finlay, Janet M.
中科院分区：
文献类型：
--
作者：
Boyce, Patricia J.;Finlay, Janet M.
影响中皮层多巴胺（DA）神经元的早期发育异常可能导致后来的功能缺陷，在青春期/成年早期出现精神疾病中发挥作用。关于这些神经元在正常或异常条件下的功能成熟知之甚少。在本研究中，6-羟多巴胺注入大鼠内侧前额叶皮层（mPFC）出生后（PN）12-14天。在PN 30 -35、45-50和60-65，使用体内微透析监测完整和损伤大鼠中mPFC细胞外DA和去甲肾上腺素（NE）浓度。完整的mPFC中的细胞外DA和NE浓度在整个发育过程中保持相当稳定;一个例外是急性尾震诱发的DA浓度随年龄增加而增加的趋势。损伤大鼠mPFC组织DA浓度持续下降（约50%）。尾震诱发的mPFC细胞外DA的增加在PN 30 -35测试的损伤大鼠中减弱，但不是PN 45 -50或60-65。基础和诱发的细胞外NE是不受影响的病变大鼠在任何年龄测试，尽管持续（约25%）减少组织NE含量。在本研究中还评估了水平运动活动。以往的研究结果表明，这种行为是由中前额叶DA神经元调制。虽然不显著，但在PN 30 -35测试的损伤大鼠中，急性尾震和急性安非他明诱发的水平运动活动倾向于减弱，在PN 60 -65测试的损伤大鼠中，其水平运动活动倾向于增强。目前的数据表明，早期部分损失的mesoprefrontal DA神经末梢，导致组织DA浓度的持续下降，是不太可能导致持续改变局部DA释放。
Early developmental abnormalities affecting mesocortical dopamine (DA) neurons may result in later functional deficits that play a role in the emergence of psychiatric illness in adolescence/early adulthood. Little is known about the functional maturation of these neurons under either normal or abnormal conditions. In the present study, 6-hydroxydopamine was infused into the rat medial prefrontal cortex (mPFC) on postnatal day (PN) 12-14. On PN30-35, 45-50, and 60-65, mPFC extracellular DA and norepinephrine (NE) concentrations were monitored in intact and lesioned rats using in vivo microdialysis. Extracellular DA and NE concentrations in the intact mPFC remain fairly stable across development; one exception being a trend for acute tailshock-evoked DA concentrations to increase as a function of age. Lesioned rats sustained a persistent (~50%) decrease in mPFC tissue DA concentrations. Tailshock-evoked increases in mPFC extracellular DA were attenuated in lesioned rats tested on PN30-35, but not PN45-50 or 60-65. Basal and evoked extracellular NE was unaffected in lesioned rats tested at any age, despite a persistent (~25%) decrease in tissue NE content. Horizontal locomotor activity was also assessed in the present study. Results of previous studies suggest this behavior is modulated by mesoprefrontal DA neurons. Although not significant, acute tailshock- and acute amphetamine-evoked horizontal locomotor activity tended to be attenuated in lesioned rats tested on PN30-35 and augmented in lesioned rats tested on PN60-65. The present data suggest that early partial loss of mesoprefrontal DA nerve terminals, resulting in a persistent decrease in tissue DA concentrations, is unlikely to result in persistent alterations in local DA release.
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影响因子：
4.2
作者：
Kiss, Janos P.
通讯作者：
Kiss, Janos P.
影响因子：
2.5
作者：
KALSBEEK, A;VOORN, P;UYLINGS, HBM
通讯作者：
UYLINGS, HBM
影响因子：
2.9
作者：
King, D;Finlay, JM
通讯作者：
Finlay, JM
影响因子：
2.5
作者：
Galineau, L;Kodas, E;Chalon, S
通讯作者：
Chalon, S
DOI：
10.1016/0165-3806(96)00004-1
发表时间：
1996-04-30
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Coulter, CL;Happe, HK;Murrin, LC
通讯作者：
Murrin, LC