Memory retrieval, reconsolidation, and extinction: Exploring the boundary conditions of post-conditioning cue exposure.

Memory retrieval, reconsolidation, and extinction: Exploring the boundary conditions of post-conditioning cue exposure.
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DOI:
10.3389/fnsyn.2023.1146665
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发表时间:
2023
影响因子:
3.7
通讯作者:
Trask, Sydney
Trask, Sydney
中科院分区:
医学3区
文献类型:
--
作者:
Ferrara, Nicole C.;Kwapis, Janine L.;Trask, Sydney

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在恐惧条件作用之后,可以通过在称为消退的过程中进行许多单独的CS呈现,或者通过呈现几个单独的CS呈现并干扰随后的记忆重新巩固来减少行为。虽然两者在程序上有相似之处,但行为结果和神经生物学基础都是不同的。在这里,我们回顾了产生这些单独的行为减少的神经和行为机制,以及决定恢复依赖的再巩固过程或灭绝过程是否有效的一些因素。
Following fear conditioning, behavior can be reduced by giving many CS-alone presentations in a process known as extinction or by presenting a few CS-alone presentations and interfering with subsequent memory reconsolidation. While the two share procedural similarities, both the behavioral outcomes and the neurobiological underpinnings are distinct. Here we review the neural and behavioral mechanisms that produce these separate behavioral reductions, as well as some factors that determine whether or not a retrieval-dependent reconsolidation process or an extinction process will be in effect.
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