Autoinducer-2-based chemical communication in bacteria: complexities of interspecies signaling.
Autoinducer-2-based chemical communication in bacteria: complexities of interspecies signaling.
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DOI：
10.1159/000219371
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Federle MJ
中科院分区：
文献类型：
--
作者：
Federle MJ
细菌中的细胞间通讯（称为群体感应）依赖于信号分子（称为自诱导剂）的产生、释放和检测。通讯使细胞群能够同步基因表达，因此以类似于多细胞生物体中的细胞的方式作为一个群体表现。大多数群体感应系统允许单个细菌种类内的通信。然而，一种称为 AI-2 的自诱导剂是由许多不同的细菌物种产生和识别的，这表明一些细菌可以跨越物种边界进行交流。目前的研究旨在发现 AI-2 在基因调控中的作用。 AI-2 的差异基因表达可能会导致细菌行为变化，例如生物膜形成或向致病状态的转变。有趣的是，存在多种检测 AI-2 的机制。这些差异可能反映了 AI-2 对不同细菌所发挥的作用的差异。此外，对 V. harveyi 中 AI-2 受体的结构分析提供了对细菌跨膜信号转导的深入了解。对细菌群体感应过程的进一步了解可能有助于开发旨在干扰细菌通讯和毒力的新技术。
Cell-cell communication in bacteria, called quorum sensing, relies on production, release, and detection of signaling molecules, termed autoinducers. Communication enables populations of cells to synchronize gene expression and therefore behave as a group in a manner akin to cells in multicellular organisms. Most quorum-sensing systems allow communication within an individual species of bacteria. However, one autoinducer, called AI-2, is produced and recognized by many different bacterial species, indicating that some bacteria communicate across species boundaries. Current studies are aimed at discovering the role that AI-2 plays in gene regulation. Differential gene expression in response to AI-2 may cause bacterial behavioral changes, such as biofilm formation or transition to a pathogenic state. Interestingly, multiple mechanisms to detect AI-2 exist. These differences likely reflect variations in the role that AI-2 plays for different bacteria. Additionally, structural analyses of the AI-2 receptor in V. harveyi have provided insight into bacterial trans-membrane signal transduction. A further understanding of bacterial quorum-sensing processes may facilitate development of new technologies aimed at interfering with bacterial communication and virulence.
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影响因子：
3.1
作者：
Day, WA;Maurelli, AT
通讯作者：
Maurelli, AT
影响因子：
3.6
作者：
Freeman, JA;Bassler, BL
通讯作者：
Bassler, BL
影响因子：
3.2
作者：
DeLisa, MP;Wu, CF;Bentley, WE
通讯作者：
Bentley, WE
影响因子：
3.6
作者：
BASSLER, BL;WRIGHT, M;SILVERMAN, MR
通讯作者：
SILVERMAN, MR
影响因子：
3.6
作者：
BASSLER, BL;WRIGHT, M;SILVERMAN, MR
通讯作者：
SILVERMAN, MR