Closed-loop stimulation using a multiregion brain-machine interface has analgesic effects in rodents.
Closed-loop stimulation using a multiregion brain-machine interface has analgesic effects in rodents.
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使用多区域脑机接口的闭环刺激对啮齿动物具有镇痛作用。
DOI：
10.1126/scitranslmed.abm5868
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发表时间：
2022-06-29
影响因子：
17.1
通讯作者：
中科院分区：
文献类型：
--
作者：
对慢性疼痛的有效治疗仍然有限。从概念上讲，将感觉信号检测与治疗传递相结合的闭环神经接口可以及时有效地缓解疼痛。由于在准确的疼痛检测和超快速的镇痛递送方面存在困难，这种系统的开发具有挑战性。疼痛具有感觉和情感成分，它们在很大程度上分别由初级体感皮层（S1）和前扣带皮层（ACC）的神经活动编码。同时，研究表明，刺激前额叶皮层（PFC）产生下行疼痛控制。在这里，我们设计并测试了一个脑机接口（BMI），它结合了一个自动疼痛检测臂，基于同时记录的S1和ACC的局部场电位（LFP）信号，以及一个治疗臂，基于自由行为大鼠PFC的光遗传激活或脑深部电刺激（DBS）。我们的多区域神经界面能够准确地检测和治疗急性疼痛和慢性疼痛。该神经界面被迅速激活，其效力随时间保持稳定。考虑到LFP记录和DBS的临床可行性，我们的研究结果表明BMI是一种很有希望的疼痛治疗方法。一个多区域脑机接口自动检测疼痛，并提供超快速镇痛急性和慢性疼痛的啮齿动物。
Effective treatments for chronic pain remain limited. Conceptually, a closed-loop neural interface combining sensory signal detection with therapeutic delivery could produce timely and effective pain relief. Such systems are challenging to develop due to difficulties in accurate pain detection and ultrafast analgesic delivery. Pain has sensory and affective components, encoded in large part by neural activities in the primary somatosensory cortex (S1) and anterior cingulate cortex (ACC), respectively. Meanwhile, studies show that stimulation of the prefrontal cortex (PFC) produces descending pain control. Here, we designed and tested a brain-machine interface (BMI) combining an automated pain detection arm, based on simultaneously recorded local field potential (LFP) signals from the S1 and ACC, with a treatment arm, based on optogenetic activation or electrical deep brain stimulation (DBS) of the PFC in freely behaving rats. Our multi-region neural interface accurately detected and treated acute evoked pain as well as chronic pain. This neural interface is activated rapidly and its efficacy remained stable over time. Given the clinical feasibility of LFP recordings and DBS, our findings suggest that BMI is a promising approach for pain treatment. A multi-region brain machine interface automatically detects pain and delivers ultrafast analgesia for acute and chronic pain in rodents.
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影响因子：
4
作者：
Chestek CA;Gilja V;Nuyujukian P;Foster JD;Fan JM;Kaufman MT;Churchland MM;Rivera-Alvidrez Z;Cunningham JP;Ryu SI;Shenoy KV
通讯作者：
Shenoy KV
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
4
作者：
Chen Z;Zhang Q;Tong APS;Manders TR;Wang J
通讯作者：
Wang J
影响因子：
2.5
作者：
Ji, Guangchen;Neugebauer, Volker
通讯作者：
Neugebauer, Volker
影响因子：
64.8
作者：
Hochberg, Leigh R.;Serruya, Mijail D.;Donoghue, John P.
通讯作者：
Donoghue, John P.