Endocrine disrupting activities of the flavonoid nutraceuticals luteolin and quercetin.
Endocrine disrupting activities of the flavonoid nutraceuticals luteolin and quercetin.
复制标题
DOI：
10.1007/s12672-013-0150-1
复制
发表时间：
2013-10
影响因子：
3
通讯作者：
Jackson TA
中科院分区：
文献类型：
--
作者：
Nordeen SK;Bona BJ;Jones DN;Lambert JR;Jackson TA
膳食中的植物类黄酮通过其抗氧化、抗炎、促凋亡和抗增殖活性，被认为对癌症预防、神经保护和心血管健康有贡献。因此，尽管对其价值和缺点了解不足，但营养保健品行业仍积极推销类黄酮补充剂，用于许多目的，包括儿科应用。我们发现两种黄酮类化合物，木犀草素和槲皮素，是混杂的内分泌干扰物。这些黄酮类化合物显示黄体酮拮抗剂活性在乳腺癌模型中有益，但在子宫内膜癌模型中有害。同时，木犀草素具有强效的雌激素激动剂活性，而槲皮素的效果要差得多。这些结果强调了黄酮类营养保健品的希望和危险，并建议在补充超过健康，富含植物的饮食所达到的水平时要谨慎。
Dietary plant flavonoids have been proposed to contribute to cancer prevention, neuroprotection, and cardiovascular health through their anti-oxidant, anti-inflammatory, pro-apoptotic, and antiproliferative activities. As a consequence, flavonoid supplements are aggressively marketed by the nutraceutical industry for many purposes, including pediatric applications, despite inadequate understanding of their value and drawbacks. We show that two flavonoids, luteolin and quercetin, are promiscuous endocrine disruptors. These flavonoids display progesterone antagonist activity beneficial in a breast cancer model but deleterious in an endometrial cancer model. Concurrently, luteolin possesses potent estrogen agonist activity while quercetin is considerably less effective. These results highlight the promise and peril of flavonoid nutraceuticals and suggest caution in supplementation beyond levels attained in a healthy, plant-rich diet.
登录
查看更多内容
影响因子：
2.9
作者：
Felix, JC;Farahmand, S
通讯作者：
Farahmand, S
影响因子：
4.7
作者：
ISHIWATA, I;ISHIWATA, C;ISHIKAWA, H
通讯作者：
ISHIKAWA, H
影响因子：
3.8
作者：
Kabos, Peter;Haughian, James M.;Wang, Xinshuo;Dye, Wendy W.;Finlayson, Christina;Elias, Anthony;Horwitz, Kathryn B.;Sartorius, Carol A.
通讯作者：
Sartorius, Carol A.
影响因子：
3
作者：
Morris, Garrett M.;Huey, Ruth;Lindstrom, William;Sanner, Michel F.;Belew, Richard K.;Goodsell, David S.;Olson, Arthur J.
通讯作者：
Olson, Arthur J.
影响因子：
5.2
作者：
Galluzzo, Paola;Martini, Chiara;Marino, Maria
通讯作者：
Marino, Maria