Gene expression plasticity and desert adaptation in house mice.
Gene expression plasticity and desert adaptation in house mice.
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家鼠的基因表达可塑性与沙漠适应。
DOI：
10.1111/evo.14172
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Nachman MW
中科院分区：
文献类型：
--
作者：
Bittner NKJ;Mack KL;Nachman MW
了解生物体如何适应新环境是进化中的一个关键问题，但目前尚不清楚表型可塑性通常是促进还是阻碍了这一过程。在这里，我们研究了进化和塑料的反应，水胁迫实验室出生的后代野生家鼠（小家鼠）收集从沙漠和非沙漠环境和测量基因表达和有机体表型控制和水胁迫条件下。在实验室中经过许多代之后，沙漠老鼠消耗的水明显少于其他地方的老鼠，这表明这种差异具有遗传基础。在水分胁迫下，沙漠小鼠比非沙漠小鼠保持更多的体重，并表现出血液化学的差异，与血液调节功能有关。肾脏中的基因表达揭示了来自不同环境的小鼠之间的进化差异，以及水合和脱水小鼠之间的塑性反应。与非沙漠小鼠相比，沙漠小鼠在水应激下表现出降低的表达可塑性。重要的是，非沙漠小鼠在水胁迫下通常表现出向沙漠样表达的转变，与适应性可塑性一致。最后，我们确定了几个共表达模块与表型的利益。这些发现为最近入侵后的局部适应提供了证据，并表明适应性可塑性可能促进了沙漠环境的殖民化。
Understanding how organisms adapt to new environments is a key problem in evolution, yet it remains unclear whether phenotypic plasticity generally facilitates or hinders this process. Here we studied evolved and plastic responses to water-stress in lab-born descendants of wild house mice (Mus musculus domesticus) collected from desert and non-desert environments and measured gene expression and organismal phenotypes under control and water-stressed conditions. After many generations in the lab, desert mice consumed significantly less water than mice from other localities, indicating that this difference has a genetic basis. Under water-stress, desert mice maintained more weight than non-desert mice, and exhibited differences in blood chemistry related to osmoregulatory function. Gene expression in the kidney revealed evolved differences between mice from different environments as well as plastic responses between hydrated and dehydrated mice. Desert mice showed reduced expression plasticity under water-stress compared to non-desert mice. Importantly, non-desert mice under water-stress generally showed shifts towards desert-like expression, consistent with adaptive plasticity. Finally, we identify several co-expression modules linked to phenotypes of interest. These findings provide evidence for local adaptation after a recent invasion and suggest that adaptive plasticity may have facilitated colonization of the desert environment.
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DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
影响因子：
2.5
作者：
Kordonowy L;Lombardo KD;Green HL;Dawson MD;Bolton EA;LaCourse S;MacManes MD
通讯作者：
MacManes MD
影响因子：
4.5
作者：
Huang Y;Agrawal AF
通讯作者：
Agrawal AF
DOI：
10.1073/pnas.1002443107
发表时间：
2010-06-22
影响因子：
11.1
作者：
Beall, Cynthia M.;Cavalleri, Gianpiero L.;Zheng, Yong Tang
通讯作者：
Zheng, Yong Tang
影响因子：
2.6
作者：
Bachmanov, AA;Reed, DR;Tordoff, MG
通讯作者：
Tordoff, MG