Recent Advances in Zein-Based Nanocarriers for Precise Cancer Therapy.
Recent Advances in Zein-Based Nanocarriers for Precise Cancer Therapy.
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DOI：
10.3390/pharmaceutics15071820
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发表时间：
2023-06-26
期刊：
影响因子：
5.4
通讯作者：
中科院分区：
文献类型：
--
作者：
癌症已成为世界范围内的主要死亡原因。然而，追求精确的癌症治疗和高效的抗肿瘤药物递送仍然是一个巨大的障碍。主要的挑战是缺乏一种具有生物可降解性、生物相容性、稳定性、靶向性和反应释放等优点的智能给药系统。玉米蛋白是一种基于植物的蛋白质，具有独特的自组装能力，可以直接或间接封装抗癌药物。利用玉米蛋白作为纳米治疗药物制剂可以保护抗癌药物免受恶劣环境的影响，如阳光、胃酸和胃蛋白酶。此外，玉米蛋白易于实现表面功能化，使其具有靶向性和刺激响应性释放能力。因此，玉米蛋白是精确递送抗癌药物的理想纳米载体。结合以往的研究经验，本文综述了玉米蛋白基抗癌药物纳米载体的制备现状。讨论了玉米蛋白基纳米载体在癌症精准治疗中的挑战、解决方案和发展趋势。这一综述将为今后肿瘤的精确治疗提供指导。
Cancer has emerged as a leading cause of death worldwide. However, the pursuit of precise cancer therapy and high-efficiency delivery of antitumor drugs remains an enormous obstacle. The major challenge is the lack of a smart drug delivery system with the advantages of biodegradability, biocompatibility, stability, targeting and response release. Zein, a plant-based protein, possesses a unique self-assembly ability to encapsulate anticancer drugs directly or indirectly. Using zein as a nanotherapeutic pharmaceutic preparation can protect anticancer drugs from harsh environments, such as sunlight, stomach acid and pepsin. Moreover, the surface functionalization of zein is easily realized, which can endow it with targeting and stimulus-responsive release capacity. Hence, zein is an ideal nanocarrier for the precise delivery of anticancer drugs. Combined with our previous research experiences, we attempt to review the current state of the preparation of zein-based nanocarriers for anticancer drug delivery. The challenges, solutions and development trends of zein-based nanocarriers for precise cancer therapy are discussed. This review will provide a guideline for precise cancer therapy in the future.
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影响因子：
8.2
作者：
Fang CY;Lou DY;Zhou LQ;Wang JC;Yang B;He QJ;Wang JJ;Weng QJ
通讯作者：
Weng QJ
影响因子：
8
作者：
Fröhlich E
通讯作者：
Fröhlich E
影响因子：
2.8
作者：
Bhattacharya, Sankha
通讯作者：
Bhattacharya, Sankha
影响因子：
3.1
作者：
Caro, Carlos;Pozo, David
通讯作者：
Pozo, David
DOI：
10.1016/j.msec.2018.04.081
发表时间：
2018-09-01
影响因子：
7.9
作者：
Chauhan, Deepak S.;Arunkumar, P.;Srivastava, Rohit
通讯作者：
Srivastava, Rohit