Bacterial mechanosensitive channels: progress towards an understanding of their roles in cell physiology.
Bacterial mechanosensitive channels: progress towards an understanding of their roles in cell physiology.
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DOI：
10.1016/j.mib.2014.01.005
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发表时间：
2014-04
影响因子：
5.4
通讯作者：
Booth, Ian R.
中科院分区：
文献类型：
--
作者：
Booth, Ian R.
大多数细菌和古细菌中都存在多个机械敏感通道。需要通道来防止在从高渗透压到低渗透压的转变过程中结构完整性的损失。通道多样性影响细胞对低渗透压应激的详细反应。越来越多的证据表明，生物体已进化出反映其生态位的 MS 通道。结构多样性可能反映了除了观察到的结构完整性保护功能之外的其他作用。细菌机械敏感通道感知水快速流入细胞所产生的细胞质膜双层侧向张力的变化。两个主要的结构家族广泛分布在细菌和古细菌中：MscL 和 MScS。通过遗传分析、结构生物学和电生理学，我们对门控机制的理解迅速推进。直到最近，对通道生理作用的分析才与机制研究保持同步。最近的进展增加了我们对通道在防止渗透转变期间结构扰动的作用及其与跨膜水流的关系的理解。本次审查正是针对这些最近的发展。
Multiple mechanosensitive channels are found in most bacteria and archaea. Channels are required to prevent loss of structural integrity during transitions from high to low osmolarity. Channel diversity feeds into the detailed response of cells to hypo-osmotic stress. There is growing evidence that organisms have evolved MS channels that reflect their niche. Structural diversity may reflect roles additional to the observed function of protection of structural integrity. Bacterial mechanosensitive channels sense the changes in lateral tension in the bilayer of the cytoplasmic membrane generated by rapid water flow into the cell. Two major structural families are found widely distributed across bacteria and archaea: MscL and MscS. Our understanding of the mechanisms of gating has advanced rapidly through genetic analysis, structural biology and electrophysiology. It is only recently that the analysis of the physiological roles of the channels has kept pace with mechanistic studies. Recent advances have increased our understanding of the role of the channels in preventing structural perturbation during osmotic transitions and its relationship to water flow across the membrane. It is to these recent developments that this review is dedicated.
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影响因子：
4.8
作者：
Folgering, JHA;Moe, PC;Poolman, B
通讯作者：
Poolman, B
影响因子：
4.4
作者：
Penn K;Jensen PR
通讯作者：
Jensen PR
DOI：
10.4161/chan.20998
发表时间：
2012-07
期刊：
Channels (Austin, Tex.)
影响因子：
--
作者：
Edwards MD;Black S;Rasmussen T;Rasmussen A;Stokes NR;Stephen TL;Miller S;Booth IR
通讯作者：
Booth IR
影响因子：
3.5
作者：
Pessi, Gabriella;Ahrens, Christian H.;Hennecke, Hauke
通讯作者：
Hennecke, Hauke
快速的多相体积适应大肠杆菌对高渗性休克。
影响因子：
3.7
作者：
Pilizota T;Shaevitz JW
通讯作者：
Shaevitz JW