Low Cost, Ease-of-Access Fabrication of Microfluidic Devices Using Wet Paper Molds.
Low Cost, Ease-of-Access Fabrication of Microfluidic Devices Using Wet Paper Molds.
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DOI：
10.3390/mi13091408
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发表时间：
2022-08-27
期刊：
影响因子：
3.4
通讯作者：
Fridman GY
中科院分区：
文献类型：
--
作者：
Thakur R;Fridman GY
快速成型方法通过使非工程学科的最终用户能够使用快速，简单和廉价的工艺制造设备，从而使微流体技术得到广泛采用。在这项工作中，我们开发了一种液体成型技术，通过复制成型来制造硅胶/PDMS微流控器件。为了构建液体模具，我们使用廉价的粘合剂背纸，醋酸盐背纸和现成的数字切割机来创建纸模具，然后我们用预定量的水湿润。由于水和PDMS的不混溶性，模具图案可以像固体模具一样有效地转移到PDMS上。我们论证了湿纸模具制造PDMS微流控器件的可行性，并评估了不同工艺参数对器件良率和质量的影响。与光刻和3D打印等传统技术相比，这种方法具有一些明显的优势。首先，我们证明了通道的横截面形状可以改变从矩形到半圆形仅仅通过修改润湿参数。其次，我们说明了如何利用电阻抗作为检查模具质量和识别缺陷的标记，而无需使用显微镜或相机等视觉工具，以非侵入性的方式。作为概念验证设备，我们创建了一个微流体t结液滴发生器，用于在矿物油中产生大小从1.2 μ L到75 μ L的水滴。我们认为这项技术是微流体快速成型工具箱的一个很好的补充，并将在生物研究中找到几个应用。
Rapid prototyping methods enable the widespread adoption of microfluidic technologies by empowering end-users from non-engineering disciplines to make devices using processes that are rapid, simple and inexpensive. In this work, we developed a liquid molding technique to create silicone/PDMS microfluidic devices by replica molding. To construct a liquid mold, we use inexpensive adhesive-backed paper, an acetate backing sheet, and an off-the-shelf digital cutter to create paper molds, which we then wet with predetermined amounts of water. Due to the immiscibility of water and PDMS, mold patterns can be effectively transferred onto PDMS similarly to solid molds. We demonstrate the feasibility of these wet paper molds for the fabrication of PDMS microfluidic devices and assess the influence of various process parameters on device yield and quality. This method possesses some distinct benefits compared to conventional techniques such as photolithography and 3D printing. First, we demonstrate that the shape of a channel’s cross-section may be altered from rectangular to semicircular by merely modifying the wetting parameters. Second, we illustrate how electrical impedance can be utilized as a marker for inspecting mold quality and identifying defects in a non-invasive manner without using visual tools such as microscopes or cameras. As a proof-of-concept device, we created a microfluidic T-junction droplet generator to produce water droplets in mineral oil ranging in size from 1.2 µL to 75 µL. We feel that this technology is an excellent addition to the microfluidic rapid prototyping toolbox and will find several applications in biological research.
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影响因子：
15.1
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