The effect of particle size on the osteointegration of injectable silicate-substituted calcium phosphate bone substitute materials.
The effect of particle size on the osteointegration of injectable silicate-substituted calcium phosphate bone substitute materials.
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DOI：
10.1002/jbm.b.32895
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发表时间：
2013-08
影响因子：
3.4
通讯作者：
Blunn, Gordon W.
中科院分区：
文献类型：
--
作者：
Coathup, Melanie J.;Cai, Qian;Campion, Charlie;Buckland, Thomas;Blunn, Gordon W.
磷酸钙（CaP）颗粒作为可注射骨填充物中的载体，允许骨缺损的微创治疗。在绵羊临界尺寸股骨髁缺损模型中，研究了泊洛沙姆填充物中改变颗粒尺寸对硅酸盐取代磷酸钙（SiCaP）骨替代材料骨整合的影响。处理组（TG）1由直径为1000-2000 μm的SiCaP颗粒（100体积%）组成。TG 2研究了250-500 μm（75体积%）的颗粒尺寸，TG 3研究了90-125 μm（75体积%）的颗粒尺寸，TG 4研究了90-125 μm（50体积%）的颗粒尺寸。在4周和8周的体内期后，对每个缺损内的骨面积、骨-植入物接触和剩余植入物面积进行定量。在4周时，与所有其他组相比，在TG 2中测量到骨形成显著增加（13.32% ± 1.38%）（所有病例中p = 0.021）。在TG 2中，与骨替代物表面接触的骨也显著更高。在8周时，大多数新骨与含有所研究的最小颗粒尺寸（在较低体积下）（TG 4）（42.78 ± 3.36%）的缺损相关，然而该组也与较高量的碎片SiCaP相关。这些较小的颗粒被巨噬细胞吞噬，似乎对愈合没有负面影响。结论：粒径为250-500 μm的SiCaP颗粒作为可注射性骨填充材料可能是一种更合适的支架材料，也可能是一种治疗骨缺损的简便方法。© 2013作者。生物医学材料研究杂志B部分：应用生物材料，由Wiley期刊公司出版。J Biomed Mater Res Part B：Appl Biomater 101 B：902-910，2013
Calcium phosphate (CaP) particles as a carrier in an injectable bone filler allows less invasive treatment of bony defects. The effect of changing granule size within a poloxamer filler on the osteointegration of silicate-substituted calcium phosphate (SiCaP) bone substitute materials was investigated in an ovine critical-sized femoral condyle defect model. Treatment group (TG) 1 consisted of SiCaP granules sized 1000–2000 μm in diameter (100 vol %). TG2 investigated a granule size of 250–500 μm (75 vol %), TG3 a granule size of 90–125 μm (75 vol %) and TG4 a granule size of 90–125 μm (50 vol %). Following a 4 and 8 week in vivo period, bone area, bone-implant contact, and remaining implant area were quantified within each defect. At 4 weeks, significantly increased bone formation was measured in TG2 (13.32% ± 1.38%) when compared with all other groups (p = 0.021 in all cases). Bone in contact with the bone substitute surface was also significantly higher in TG2. At 8 weeks most new bone was associated within defects containing the smallest granule size investigated (at the lower volume) (TG4) (42.78 ± 3.36%) however this group was also associated with higher amounts of fragmented SiCaP. These smaller particles were phagocytosed by macrophages and did not appear to have a negative influence on healing. In conclusion, SiCaP granules of 250–500 μm in size may be a more suitable scaffold when used as an injectable bone filler and may be a convenient method for treating bony defects. © 2013 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 902–910, 2013
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影响因子：
4.3
作者：
SHAPOFF, CA;BOWERS, GM;YUKNA, A
通讯作者：
YUKNA, A
影响因子：
2.7
作者：
Weissenboeck, Martina;Stein, Elisabeth;Turhani, Dritan
通讯作者：
Turhani, Dritan
影响因子：
5.3
作者：
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通讯作者：
Renton L
影响因子：
14
作者：
Fellah, Borhane H.;Gauthier, Olivier;Layrolle, Pierre
通讯作者：
Layrolle, Pierre
DOI：
10.1097/00003086-198604000-00036
发表时间：
1986-04-01
影响因子：
4.2
作者：
SCHMITZ, JP;HOLLINGER, JO
通讯作者：
HOLLINGER, JO