Fabrication of nonwoven coaxial fiber meshes by electrospinning.
Fabrication of nonwoven coaxial fiber meshes by electrospinning.
复制标题
DOI：
10.1089/ten.tec.2008.0422
复制
发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
Mikos AG
中科院分区：
文献类型：
--
作者：
Saraf A;Lozier G;Haesslein A;Kasper FK;Raphael RM;Baggett LS;Mikos AG
因此，人们迫切需要能够调控药物、质粒和蛋白质等生物活性因子释放的生物可降解聚合物支架。同轴静电纺丝是一种新的技术，目前正在探索通过将水基生物分子嵌入其中来创建这种聚合物支架。在这项研究中，我们评估了各种工艺参数，如鞘聚合物浓度，芯聚合物浓度和分子量，和盐离子内的芯聚合物对同轴纤维形态的影响。本研究中使用的鞘聚合物是聚（ε-己内酯）（PCL），芯聚合物是聚（乙二醇）（PEG）。我们研究了各种工艺参数对芯直径，总纤维直径和鞘厚度的同轴微纤维，使用24全析因统计模型的影响。随着鞘聚合物（PCL）浓度从9wt%（0.49 ± 0.03 μm）增加到11wt%（0.49 ± 0.03 μm）和芯内盐浓度从0增加到500 mM（0.38 ± 0.03 μm），观察到总纤维直径的最大增加。芯纤维直径受皮和芯聚合物（分别为PCL和PEG）浓度的影响最大，后者从200 mg/ml增加到400 mg/ml（分别为0.40 ± 0.01 μm和0.36 ± 0.01 μm）。核心聚合物（PEG）浓度对鞘厚度有最大的负面影响（0.40 ± 0.03 μm），而盐浓度对鞘厚度有最大的正面影响（0.28 ± 0.03 μm）。芯聚合物（PEG）的分子量从1.0 kDa增加到4.6 kDa，导致总纤维直径和鞘纤维直径以及鞘厚度适度增加。这些实验提供了重要的信息，奠定了合成的同轴光纤与可调尺寸所需的基础。
There is a great need for biodegradable polymer scaffolds that can regulate the delivery of bioactive factors such as drugs, plasmids and proteins. Coaxial electrospinning is a novel technique that is currently being explored to create such polymer scaffolds by embedding within them aqueous based biological molecules. In this study we evaluated the influence of various processing parameters such as sheath polymer concentration, core polymer concentration and molecular weight, and salt ions within the core polymer on coaxial fiber morphology. The sheath polymer used in this study was poly(ε-caprolactone) (PCL) and the core polymer was poly(ethylene glycol) (PEG). We examined the effects of the various processing parameters on core diameters, total fiber diameters and sheath thicknesses of coaxial microfibers using a 24 full factorial statistical model. The maximum increase in total fiber diameter was observed with increase in sheath polymer (PCL) concentration from 9 to 11 wt % (0.49 ± 0.03 μm) and salt concentration within the core from 0 to 500 mM (0.38 ± 0.03 μm). The core fiber diameter was most influenced by the sheath and core polymers (PCL and PEG, respectively) concentrations, the latter of which increased from 200 to 400 mg/ml (0.40 ± 0.01 μm and 0.36 ± 0.01 μm, respectively). The core polymer (PEG) concentration had a maximal negative effect on sheath thickness (0.40 ± 0.03 μm), while salt concentration had the maximal positive effect (0.28 ± 0.03 μm). Molecular weight increases in core polymer (PEG) from 1.0 kDa to 4.6 kDa caused moderate increases in total and sheath fiber diameters and sheath thicknesses. These experiments provide important information that lays the foundation required for the synthesis of coaxial fibers with tunable dimensions.
登录
查看更多内容
影响因子：
3
作者：
Eda, Goki;Liu, James;Shivkumar, Satya
通讯作者：
Shivkumar, Satya
DOI：
10.1002/jbm.b.30510
发表时间：
2006-10-01
影响因子：
3.4
作者：
Jiang, Hongliang;Hu, Yingqian;Zhu, Kangjie
通讯作者：
Zhu, Kangjie
影响因子：
2.5
作者：
Kang, Yun Kyung;Park, Chung Hee;Kang, Tae Jin
通讯作者：
Kang, Tae Jin
DOI：
10.1007/s00339-007-4330-0
发表时间：
2008-03-01
影响因子：
2.7
作者：
Kim, Geun Hyung;Yoon, Hyeon
通讯作者：
Yoon, Hyeon
DOI：
10.1016/j.colsurfa.2007.04.129
发表时间：
2008-02-01
影响因子：
5.2
作者：
Chen, Jyh-Ping;Chang, Gwo-Yun;Chen, Jan-Kan
通讯作者：
Chen, Jan-Kan