Bone Graft Prefabrication Following the In Vivo Bioreactor Principle.
Bone Graft Prefabrication Following the In Vivo Bioreactor Principle.
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遵循体内生物反应器原理的骨移植预制
DOI：
10.1016/j.ebiom.2016.09.016
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发表时间：
2016-10
期刊：
影响因子：
11.1
通讯作者：
Li, Qingfeng
中科院分区：
文献类型：
--
作者：
Huang, Ru-Lin;Kobayashi, Eiji;Liu, Kai;Li, Qingfeng
由于功能和美学重建的困难，大面积骨缺损的治疗是一个巨大的挑战。通过体外操作生物支架、种子细胞和生长因子构建的组织工程化骨移植物被认为是骨缺损重建的潜在治疗方法。然而，在实验成功和临床转化之间仍然存在巨大差距。一个新兴的战略，弥补这一差距是使用在体内生物反应器的原则和皮瓣预制技术。这一原则的重点是使用身体作为生物反应器来培养传统的三要素（生物支架，种子细胞和生长因子），并利用身体的自我再生能力来再生新组织。此外，皮瓣预制技术允许再生骨移植物作为预制骨瓣转移用于骨缺损重建。这种策略已成功地用于重建动物模型和人类的临界尺寸的骨缺损。在这里，我们强调这一概念，并提供一些关于如何将当前的知识转化为临床实践的观点。体内生物反应器原理和皮瓣预制技术是一种很有前途的骨缺损修复策略。体内生物反应器的原理集中在利用身体的自我再生能力来再生新组织。该策略已成功用于重建人类临界尺寸的骨缺损。
Large bone defect treatment represents a great challenge due to the difficulty of functional and esthetic reconstruction. Tissue-engineered bone grafts created by in vitro manipulation of bioscaffolds, seed cells, and growth factors have been considered potential treatments for bone defect reconstruction. However, a significant gap remains between experimental successes and clinical translation. An emerging strategy for bridging this gap is using the in vivo bioreactor principle and flap prefabrication techniques. This principle focuses on using the body as a bioreactor to cultivate the traditional triad (bioscaffolds, seed cells, and growth factors) and leveraging the body's self-regenerative capacity to regenerate new tissue. Additionally, flap prefabrication techniques allow the regenerated bone grafts to be transferred as prefabricated bone flaps for bone defect reconstruction. Such a strategy has been used successfully for reconstructing critical-sized bone defects in animal models and humans. Here, we highlight this concept and provide some perspective on how to translate current knowledge into clinical practice. The in vivo bioreactor principle and flap prefabrication technique is a promising strategy for bone defect reconstruction. The in vivo bioreactor principle focuses on using the body’s self-regenerative capacity to regenerate new tissue. This strategy has been successfully used to reconstruct critical-sized bone defects in humans.
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影响因子：
3.3
作者：
Boos, Anja M.;Loew, Johanna S.;Beier, Justus P.
通讯作者：
Beier, Justus P.
DOI：
10.2741/s132
发表时间：
2011-01-01
期刊：
Frontiers in bioscience (Scholar edition)
影响因子：
--
作者：
Binderman, Itzhak;Yaffe, Avinoam;Bahar, Hila
通讯作者：
Bahar, Hila
影响因子：
4
作者：
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通讯作者：
Yoo, J. J.
影响因子：
1.6
作者：
Beier, J. P.;Hess, A.;Kneser, U.
通讯作者：
Kneser, U.
影响因子：
3
作者：
Arkudas, Andreas;Beier, Justus Patrick;Kneser, Ulrich
通讯作者：
Kneser, Ulrich