Saliva microbiome alterations in dental fluorosis population.
Saliva microbiome alterations in dental fluorosis population.
复制标题
DOI：
10.1080/20002297.2023.2180927
复制
发表时间：
2023
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
我们的目的是探索氟斑牙人群唾液微生物组的变化。对957名大学生氟斑牙患病率进行了调查。 Dean氟斑牙指数用于评估氟斑牙状况。在这些患者的子集（100 名健康对照者，100 名氟斑牙患者）中评估了唾液微生物组组成的变化。氟斑牙影响了 47% 的学生样本，且发病率与性别无关。与健康对照相比，氟斑牙患者的微生物群多样性增加，解卵磷脂螺旋体、麦氏弧菌、少铜菌、假单胞菌、假单胞菌科、假单胞菌的丰度增加，而变形链球菌、血链球菌、双子菌和葡萄球菌的丰度减少。功能分析显示，氟斑牙患者的精氨酸生物合成增加，同时氨基糖和核苷酸糖代谢、果糖和甘露糖代谢、淀粉和蔗糖代谢减少。这些结果表明健康对照者和氟斑牙患者之间的唾液微生物组存在显着差异。氟斑牙可能导致牙周炎和全身性肺部疾病。需要进行队列研究来确定改变氟斑牙患者的唾液微生物群是否可以改变口腔或全身疾病的发展。
We aimed to explore saliva microbiome alterations in dental fluorosis population. The prevalence of dental fluorosis was examined in 957 college students. Dean’s fluorosis index was used to evaluate the dental fluorosis status. Changes in the composition of the salivary microbiome were assessed in a subset of these patients (100 healthy controls, 100 dental fluorosis patients). Dental fluorosis affected 47% of the student sample, and incidence was unrelated to gender. Compared with healthy controls, the microbiota of patients with dental fluorosis exhibited increased diversity, with increased abundance of Treponema lecithinolyticum, Vibrio metschnikovii, Cupriavidus pauculus, Pseudomonas, Pseudomonadaceae, Pseudomonadales, and decreased abundance of Streptococcus mutans, Streptococcus sanguinis, Gemella, and Staphylococcales. Function analyses showed increases in arginine biosynthesis in patients affected by dental fluorosis, together with reductions in amino sugar and nucleotide sugar metabolism, fructose and mannose metabolism, and starch and sucrose metabolism. These results suggest that there are striking differences in salivary microbiome between healthy controls and dental fluorosis patients. Dental fluorosis may contribute to periodontitis and systemic lung diseases. There is a need for cohort studies to determine whether altering the salivary microbiota in dental fluorosis patients can alter the development of oral or systemic diseases.
登录
查看更多内容
影响因子：
--
作者：
DenBesten P;Li W
通讯作者：
Li W
影响因子：
5.9
作者：
Bobin-Dubigeon C;Luu HT;Leuillet S;Lavergne SN;Carton T;Le Vacon F;Michel C;Nazih H;Bard JM
通讯作者：
Bard JM
影响因子：
3.7
作者：
Abranches J;Zeng L;Kajfasz JK;Palmer SR;Chakraborty B;Wen ZT;Richards VP;Brady LJ;Lemos JA
通讯作者：
Lemos JA
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
4.4
作者：
AlEraky DM;Madi M;El Tantawi M;AlHumaid J;Fita S;AbdulAzeez S;Borgio JF;Al-Harbi FA;Alagl AS
通讯作者：
Alagl AS