In situ saxs characterization of thermoresponsive behavior of a poly(ethylene glycol)-graft-(poly(vinyl caprolactam)-co-poly(vinyl acetate)) amphiphilic graft copolymer
In situ saxs characterization of thermoresponsive behavior of a poly(ethylene glycol)-graft-(poly(vinyl caprolactam)-co-poly(vinyl acetate)) amphiphilic graft copolymer
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聚（乙二醇）-接枝-（聚（乙烯基己内酰胺）-共聚（乙酸乙烯酯））两亲接枝共聚物的热响应行为的原位萨克斯表征
DOI：
10.1088/1361-6528/acab6d
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发表时间：
2023
期刊：
影响因子：
3.5
通讯作者：
Bhatia, Surita R
中科院分区：
文献类型：
--
作者：
Kennedy, Mitchell A;Zhang, Yugang;Bhatia, Surita R
我们报告了两亲性热敏接枝共聚物聚（乙二醇）-接枝-（聚（乙烯基己内酰胺）-共聚（乙酸乙烯酯））（商品名 Soluplus®）的热响应组装和流变学，并已对其潜在的生物医学应用进行了研究。由于其能够溶解疏水性药物以及其接近体温的增稠行为而受到关注。通过使用布鲁克海文国家实验室的同步加速器以及与能源部的合作，可以更详细地探测纳米级结构和特性。随着温度升高，Soluplus® 会经历两种结构变化；第一个是与浓度无关的变化，样品在 32°C 下变得浑浊。升高温度进一步导致物理关联的水凝胶的形成。这种溶胶-凝胶转变是浓度依赖性的，对于 40 wt% 的样品，发生在 32°C，对于 10 wt% 的样品，温度升高到 42°C。从可变温度 SAXS 表征中可以看到半径为 20-25 nm 的胶束，并在 32°C 以下保持其尺寸和堆积。还观察到与材料增稠相对应的胶束聚集逐渐增加。接近或高于胶凝温度时，胶束会塌陷并形成物理关联的 3D 网络。提出了一个模型来解释这些物理效应，其中聚（乙烯基己内酰胺）基团随着温度升高从室温下的亲水性冠转变为疏水性核。
We report the thermoresponsive assembly and rheology of an amphiphilic thermosensitive graft copolymer, poly (ethylene glycol)-graft-(poly (vinyl caprolactam)-co-poly (vinyl acetate))(commercial name Soluplus®), which has been investigated for potential biomedical applications. It has received attention due to is ability to solubilize hydrophobic drugs and for its thickening behavior close to body temperature. Through use of the synchrotron at Brookhaven National Lab, and collaboration with the department of energy, the nanoscale structure and properties can be probed in greater detail. Soluplus® undergoes two structural changes as temperature is increased; the first, a concentration independent change where samples become turbid at 32 C. Increasing the temperature further causes the formation of physically associated hydrogels. This sol-gel transition is concentration dependent and occurs at 32 C for 40 wt% samples, and increases to 42 C for 10 wt% samples. From variable temperature SAXS characterization micelles of 20–25 nm in radius can be seen and maintain their size and packing below 32 C. A gradual increase in the aggregation of micelles corresponding to a thickening of the material is also observed. Close to and above the gelation temperature, micelles collapse and form a physically associated 3D network. A model is proposed to explain these physical effects, where the poly (vinyl caprolactam) group transitions from the hydrophilic corona at room temperature to the hydrophobic core as temperature is increased.
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影响因子：
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作者：
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DOI：
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