Neurological outcomes associated with low-level manganese exposure in an inception cohort of asymptomatic welding trainees.
Neurological outcomes associated with low-level manganese exposure in an inception cohort of asymptomatic welding trainees.
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与低水平锰暴露有关的神经结局，在无症状焊接学员中。
DOI：
10.5271/sjweh.3466
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Seixas NS
中科院分区：
文献类型：
--
作者：
Baker MG;Criswell SR;Racette BA;Simpson CD;Sheppard L;Checkoway H;Seixas NS
长期高水平暴露于锰（Mn）与中枢神经系统（CNS）功能受损有关。我们定量地探讨了低水平锰暴露与选择的神经系统预后之间的关系，在纵向初始队列的无症状焊工学员。在为期五个季度的培训过程中，大约每三个月观察一次以前没有职业锰暴露的焊工。采用统一帕金森病评定量表运动分部分第3部分（UPDRS3）和槽钉板测试对56名焊工的运动功能进行评估。17个子集也进行了MRI扫描以评估t1加权指数。在研究期间，使用混合模型定量评估焊接烟尘中锰的个人暴露，以获得按焊接类型估计的受试者特定暴露水平。将这些估计值相加，以估计每次神经预后测试时的累积暴露量。在调整了可能的学习效应后，累积暴露与UPDRS3评分或凹槽钉板时间之间没有关联。基底神经节的t1加权指数（尾状核、前壳核、后壳核和联合基底神经节，但不包括pallidal指数）显示出与累积Mn暴露增加相关的信号强度的统计学显著增加。这项研究表明，即使在临床上出现明显的缺陷之前，人类在极低水平的暴露下也可以在大脑中检测到t1加权变化。这表明，通过持续的随访，我们可以确定临床症状开始显现的T1毒性阈值。
Long-term, high-level exposure to manganese (Mn) is associated with impaired central nervous system (CNS) function. We quantitatively explored relations between low-level Mn exposure and selected neurological outcomes in a longitudinal inception cohort of asymptomatic welder trainees. Welders with no previous occupational Mn exposure were observed approximately every three months over the course of the five-quarter traineeship. Fifty-six welders were assessed for motor function using the Unified Parkinson Disease Rating Scale motor subsection part 3 (UPDRS3) and Grooved Pegboard tests. A subset of 17 also had MRI scans to assess T1-weighted indices. Personal exposure to Mn in welding fume was quantitatively assessed during the study period using a mixed model to obtain estimates of subject-specific exposure level by welding type. These estimates were summed to estimate cumulative exposure at the time of each neurological outcome test. When adjusting for possible learning effects, there were no associations between cumulative exposure and UPDRS3 score or Grooved Pegboard time. T1-weighted indices of the basal ganglia (caudate, anterior putamen, posterior putamen, and combined basal ganglia, but not the pallidal index) exhibited statistically significant increases in signal intensity in relation to increased cumulative Mn exposure. This study demonstrates that T1-weighted changes can be detected in the brain even at very low levels of exposure among humans before any clinically evident deficits. This suggests that with continued follow-up we could identify a T1 threshold of toxicity at which clinical symptoms begin to manifest.
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影响因子：
2
作者：
Baker MG;Simpson CD;Stover B;Sheppard L;Checkoway H;Racette BA;Seixas NS
通讯作者：
Seixas NS
影响因子：
3.4
作者：
Laohaudomchok W;Lin X;Herrick RF;Fang SC;Cavallari JM;Shrairman R;Landau A;Christiani DC;Weisskopf MG
通讯作者：
Weisskopf MG
影响因子：
4.4
作者：
LARSEN N A;PAKKENBERG H;HEYDORN K
通讯作者：
HEYDORN K
影响因子：
3.4
作者：
Antonini, James M.;Santaimaria, Annette B.;Lucchini, Roberto
通讯作者：
Lucchini, Roberto
影响因子：
4.9
作者：
Criswell SR;Perlmutter JS;Huang JL;Golchin N;Flores HP;Hobson A;Aschner M;Erikson KM;Checkoway H;Racette BA
通讯作者：
Racette BA