Cortisol diurnal rhythm and stress reactivity in male adolescents with early-onset or adolescence-onset conduct disorder.
Cortisol diurnal rhythm and stress reactivity in male adolescents with early-onset or adolescence-onset conduct disorder.
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DOI：
10.1016/j.biopsych.2008.05.022
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发表时间：
2008-10-01
影响因子：
10.6
通讯作者：
Goodyer, Ian M.
中科院分区：
文献类型：
--
作者：
Fairchild, Graeme;van Goozen, Stephanie H. M.;Stollery, Sarah J.;Brown, Jamie;Gardiner, Julian;Herbert, Joe;Goodyer, Ian M.
关键词：
先前的研究已经报道了患有品行障碍（CD）的儿童和青少年的基础皮质醇水平较低，皮质醇对压力的反应也较低。尚不清楚这些结果是否特异于早发性CD。本研究调查了早发性和复发性CD男性受试者的基础和应激诱导的皮质醇分泌。42名早发性CD受试者、28名复发性CD受试者和95名对照受试者参加了这项研究。他们收集了一天中的唾液，以评估他们的皮质醇觉醒反应和昼夜节律。随后，唾液皮质醇测量之前，期间和之后的心理压力程序，旨在引起挫折。心血管活动和主观情绪状态也进行了评估，在压力暴露。早晨皮质醇水平或皮质醇觉醒反应的大小没有组间差异。在实验室访视期间，两个CD亚组中晚上和上午11点的基础皮质醇水平均高于对照受试者。与此相反，皮质醇和心血管反应的心理社会压力减少，在两个CD亚组与对照组相比。所有的小组都报告了在压力下消极情绪状态的相似增加。我们的研究结果表明，皮质醇分泌的组间差异是最明显的压力暴露，当参与者与CD显示皮质醇低反应与对照组相比。没有证据表明CD参与者的基础皮质醇分泌减少，而是在特定时间点增加分泌。结果不支持CD亚型之间皮质醇分泌的发育敏感性差异。
Previous studies have reported lower basal cortisol levels and reduced cortisol responses to stress in children and adolescents with conduct disorder (CD). It is not known whether these findings are specific to early-onset CD. This study investigated basal and stress-induced cortisol secretion in male participants with early-onset and adolescence-onset forms of CD. Forty-two participants with early-onset CD, 28 with adolescence-onset CD, and 95 control subjects participated in the study. They collected saliva across the day to assess their cortisol awakening response and diurnal rhythm. Subsequently, salivary cortisol was measured before, during, and after a psychosocial stress procedure designed to elicit frustration. Cardiovascular activity and subjective mood states were also assessed during stress exposure. There were no group differences in morning cortisol levels or the size of the cortisol awakening response. Basal cortisol levels in the evening and at 11 am during the laboratory visit were higher in both CD subgroups relative to control subjects. In contrast, cortisol and cardiovascular responses to psychosocial stress were reduced in both CD subgroups compared with control subjects. All groups reported similar increases in negative mood states during stress. Our findings suggest that group differences in cortisol secretion are most pronounced during stress exposure, when participants with CD show cortisol hyporeactivity compared with control subjects. There was no evidence for reduced basal cortisol secretion in participants with CD, but rather increased secretion at specific time points. The results do not support developmentally sensitive differences in cortisol secretion between CD subtypes.
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DOI：
10.1097/00004583-200404000-00012
发表时间：
2004-04-01
影响因子：
13.3
作者：
Azar, R;Zoccolillo, M;Tremblay, RE
通讯作者：
Tremblay, RE
影响因子：
10.6
作者：
Moss, HB;Vanyukov, M;Kirillova, GP
通讯作者：
Kirillova, GP
影响因子：
3.7
作者：
Pruessner, JC;Kirschbaum, C;Hellhammer, DH
通讯作者：
Hellhammer, DH
影响因子：
6.1
作者：
Pruessner, JC;Wolf, OT;Kirschbaum, C
通讯作者：
Kirschbaum, C
影响因子：
--
作者：
Pajer, K;Gardner, W;Neal, S
通讯作者：
Neal, S