3D bioprinting for skin tissue engineering: Current status and perspectives.

3D bioprinting for skin tissue engineering: Current status and perspectives.
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皮肤组织工程 3D 生物打印:现状和前景

DOI:
10.1177/20417314211028574
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发表时间:
2021-01
影响因子:
8.2
通讯作者:
Wang X
Wang X
中科院分区:
工程技术1区
文献类型:
--
作者:
Weng T;Zhang W;Xia Y;Wu P;Yang M;Jin R;Xia S;Wang J;You C;Han C;Wang X

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皮肤和皮肤附属物容易受伤,需要快速可靠的再生方法。近年来,3D生物打印显示出伤口修复和再生的潜力。3D生物打印可以根据皮肤形状进行定制,细胞和其他材料精确分布,实现仿生皮肤替代品的快速可靠生产,从而满足临床和工业需求。此外,它具有高分辨率,灵活性,可重复性和高通量的优异性能,显示了巨大的潜力,用于组织工程皮肤的制造。本文介绍了3D生物打印的常用技术及其在皮肤组织工程中的应用,重点介绍了皮肤附属器(毛囊和汗腺)和血管化方面的最新研究进展,并总结了3D皮肤打印技术目前面临的挑战和未来的发展。
Skin and skin appendages are vulnerable to injury, requiring rapidly reliable regeneration methods. In recent years, 3D bioprinting has shown potential for wound repair and regeneration. 3D bioprinting can be customized for skin shape with cells and other materials distributed precisely, achieving rapid and reliable production of bionic skin substitutes, therefore, meeting clinical and industrial requirements. Additionally, it has excellent performance with high resolution, flexibility, reproducibility, and high throughput, showing great potential for the fabrication of tissue-engineered skin. This review introduces the common techniques of 3D bioprinting and their application in skin tissue engineering, focusing on the latest research progress in skin appendages (hair follicles and sweat glands) and vascularization, and summarizes current challenges and future development of 3D skin printing.
DOI: 10.1016/j.mattod.2015.05.002
发表时间: 2015-12
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