Lung cancer risk by geologic coal deposits: A case-control study of female never-smokers from Xuanwei and Fuyuan, China.
Lung cancer risk by geologic coal deposits: A case-control study of female never-smokers from Xuanwei and Fuyuan, China.
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DOI：
10.1002/ijc.32034
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发表时间：
2019-06-15
影响因子：
6.4
通讯作者：
Lan, Qing
中科院分区：
文献类型：
--
作者：
Wong, Jason Y. Y.;Downward, George S.;Hu, Wei;Portengen, Lutzen;Seow, Wei Jie;Silverman, Debra T.;Bassig, Bryan A.;Zhang, Jinming;Xu, Jun;Ji, Bu-Tian;Li, Jihua;He, Jun;Yang, Kaiyun;Tian, Linwei;Shen, Min;Huang, Yunchao;Vermeulen, Roel;Rothman, Nathaniel;Lan, Qing
关键词：
煤的类型因其来源矿床的地球化学差异而在世界各地各不相同;然而，不同矿床的煤排放对人类健康的影响仍未得到探索。为了解决这一问题，我们在宣威和富源两个县进行了第一次研究，探讨了不同矿床的煤炭使用量与肺癌风险之间的关系。宣威和富源两个县是世界上不吸烟女性肺癌发病率最高的地区之一，因为她们使用烟煤取暖和做饭。我们对宣威市和抚远市1031例肺癌患者和493例对照者进行了一项基于人群的病例对照研究。Logistic回归模型被用来估计整个生命周期中各种沉积物的煤炭使用与肺癌风险之间的关联。煤炭存款的风险存在很大的异质性。与非烟煤用户相比，烟煤存款的风险范围为-。此外，出生在使用冒烟的煤，后来改为无烟煤的家庭的妇女比出生在使用无烟煤，后来改为冒烟的煤的家庭的妇女有更高的风险。我们的研究表明，不同来源的煤炭对这一人群的肺癌有相当不同的影响，并表明早期生活中暴露于致癌排放物可能会对以后生活中的健康风险产生重大影响。在评估接触燃煤排放物所造成的健康风险时，应考虑这些因素。
Coal types vary around the world because of geochemical differences in their source deposits; however, the influence of coal emissions from different deposits on human health remains unexplored. To address this issue, we conducted the first study of the relationship between coal use from various deposits and lung cancer risk in Xuanwei and Fuyuan, counties in China where lung cancer rates are among the highest in the world among female never-smokers due to use of bituminous (“smoky”) coal for heating and cooking. We conducted a population-based case–control study of 1031 lung cancer cases and 493 controls among never-smoking women in Xuanwei and Fuyuan. Logistic regression models were used to estimate associations between coal use from various deposits across the lifecourse and lung cancer risk. There was substantial heterogeneity in risks by coal deposit . Compared to non-smoky coal users, risks by smoky coal deposit ranged from to . Further, women born into homes that used smoky coal and subsequently changed to non-smoky coal had a higher risk than women born into homes that used non-smoky coal and changed to smoky coal . Our study demonstrates that various sources of coal have considerably different impact on lung cancer in this population and suggests that early-life exposure to carcinogenic emissions may exert substantial influence on health risks later in life. These factors should be considered when evaluating the health risks posed by exposure to coal combustion emissions.
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影响因子：
11.8
作者：
Downward, George S.;Hu, Wei;Large, David;Veld, Harry;Xu, Jun;Reiss, Boris;Wu, Guoping;Wei, Fusheng;Chapman, Robert S.;Rothman, Nat;Qing, Lan;Vermeulen, Roel
通讯作者：
Vermeulen, Roel
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影响因子：
10.4
作者：
Li J;Zhu X;Yu K;Jiang H;Zhang Y;Wang B;Liu X;Deng S;Hu J;Deng Q;Sun H;Guo H;Zhang X;Chen W;Yuan J;He M;Bai Y;Han X;Liu B;Liu C;Guo Y;Zhang B;Zhang Z;Hu FB;Gao W;Li L;Lathrop M;Laprise C;Liang L;Wu T
通讯作者：
Wu T
影响因子：
11.4
作者：
Hu, Wei;Downward, George S.;Reiss, Boris;Xu, Jun;Bassig, Bryan A.;Hosgood, H. Dean, III;Zhang, Linlin;Seow, Wei Jie;Wu, Guoping;Chapman, Robert S.;Tian, Linwei;Wei, Fusheng;Vermeulen, Roel;Lan, Qing
通讯作者：
Lan, Qing
DOI：
10.1073/pnas.96.7.3427
发表时间：
1999-03-30
影响因子：
11.1
作者：
Finkelman, RB;Belkin, HE;Zheng, BS
通讯作者：
Zheng, BS
影响因子：
4.7
作者：
Mumford, JL;Li, XM;Chuang, JC
通讯作者：
Chuang, JC