Maternal depression and adverse neighbourhood conditions during pregnancy are associated with gestational epigenetic age deceleration.
Maternal depression and adverse neighbourhood conditions during pregnancy are associated with gestational epigenetic age deceleration.
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DOI：
10.1080/15592294.2022.2090657
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发表时间：
2022-12
期刊：
影响因子：
3.7
通讯作者：
Holdsworth, Elizabeth A.
中科院分区：
文献类型：
--
作者：
Appleton, Allison A.;Lin, Betty;Kennedy, Elizabeth M.;Holdsworth, Elizabeth A.
关键词：
妊娠表观遗传年龄 (GEA) 的加速和减速可以指示发育风险，并可能有助于阐明产前暴露如何导致后代结果。怀孕期间的抑郁症和社区状况是出生和儿童结局的明确决定因素。最新研究表明，母亲抑郁症可能会导致 GEA 减速。目前尚不清楚产前的社区逆境是否也会影响 GEA 的减速。本研究探讨了母亲抑郁症和邻里条件是否独立或共同导致 GEA 减速，以及哪些社会和环境邻里条件与 GEA 相关。参与者来自奥尔巴尼婴儿和母亲研究（n = 204），这是一个由高风险种族/民族多样化母亲/婴儿二人组成的前瞻性非概率抽样队列。 GEA 是根据脐带血估算的。在怀孕期间评估抑郁症状和人口普查区水平的邻里状况。母亲抑郁症（β=−0.03，SE=0.01，p=0.008）和邻里逆境（β=−0.32，SE=0.14，p=0.02）与 GEA 减速独立相关，控制了所有协变量，包括抗抑郁药物的使用和细胞类型比例。邻里逆境并没有改变母亲抑郁症与 GEA 的关联（β = 0.003，SE = 0.03，p = 0.92）。社区贫困程度较高、公共援助和缺乏健康食品均与 GEA 减速有关；较高的小学考试成绩（社区税基指标）与 GEA 加速相关（所有 p < 0.001）。这项研究的结果表明，在这个不同的人群中，母亲抑郁症和邻里状况是独立且累积相关的 GEA。
Gestational epigenetic age (GEA) acceleration and deceleration can indicate developmental risk and may help elucidate how prenatal exposures lead to offspring outcomes. Depression and neighbourhood conditions during pregnancy are well-established determinants of birth and child outcomes. Emerging research suggests that maternal depression may contribute to GEA deceleration. It is unknown whether prenatal neighbourhood adversity would likewise influence GEA deceleration. This study examined whether maternal depression and neighbourhood conditions independently or jointly contributed to GEA deceleration, and which social and environmental neighbourhood conditions were associated with GEA. Participants were from the Albany Infant and Mother Study (n = 204), a prospective non-probability sampled cohort of higher risk racial/ethnic diverse mother/infant dyads. GEA was estimated from cord blood. Depressive symptoms and census-tract level neighbourhood conditions were assessed during pregnancy. Maternal depression (β = −0.03, SE = 0.01, p = 0.008) and neighbourhood adversity (β = −0.32, SE = 0.14, p = 0.02) were independently associated with GEA deceleration, controlling for all covariates including antidepressant use and cell type proportions. Neighbourhood adversity did not modify the association of maternal depression and GEA (β = 0.003, SE = 0.03, p = 0.92). igher levels of neighbourhood poverty, public assistance, and lack of healthy food access were each associated with GEA deceleration; higher elementary school test scores (an indicator of community tax base) were associated with GEA acceleration (all p < 0.001). The results of this study indicated that maternal depression and neighbourhood conditions were independently and cumulatively associated GEA in this diverse population.
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影响因子：
5.7
作者：
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5.7
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通讯作者：
Czamara D
影响因子：
4
作者：
Bonevski B;Randell M;Paul C;Chapman K;Twyman L;Bryant J;Brozek I;Hughes C
通讯作者：
Hughes C
DOI：
10.3390/ijerph182212169
发表时间：
2021-11-19
影响因子：
--
作者：
Appleton AA;Kiley KC;Schell LM;Holdsworth EA;Akinsanya A;Beecher C
通讯作者：
Beecher C