Prenatal Lead and Depression Exposures Jointly Influence Birth Outcomes and NR3C1 DNA Methylation.
Prenatal Lead and Depression Exposures Jointly Influence Birth Outcomes and NR3C1 DNA Methylation.
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DOI：
10.3390/ijerph182212169
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发表时间：
2021-11-19
影响因子：
--
通讯作者：
Beecher C
中科院分区：
文献类型：
--
作者：
Appleton AA;Kiley KC;Schell LM;Holdsworth EA;Akinsanya A;Beecher C
许多孕期暴露会影响分娩结果，但毒物和心理社会因素的共同作用尚未得到充分研究。此外，相关的妊娠表观遗传机制尚不清楚。铅和抑郁症独立影响出生结局和后代NR3C1(糖皮质激素受体)DNA甲基化。我们假设妊娠期铅和抑郁症将共同影响出生结果和NR3C1甲基化。怀孕暴露信息、DNA甲基化和出生结局数据是从n=272对母婴中前瞻性收集的。采用因子分析对NR3C1进行降维。对孕期铅和抑郁暴露与出生结局和NR3C1之间的交互作用进行了多变量线性回归检验。交互作用表明，较高水平的铅和抑郁共同导致早孕、出生时婴儿较小以及胎儿发育不对称。PB和抑郁症也与解释NR3C1甲基化变异最大的两个主要因素得分共同相关；NR3C1得分与一些婴儿结局有关，包括胎龄和胎儿不对称生长。铅中毒和抑郁症可以累积影响出生结局和表观遗传机制，这可能为以后的健康风险奠定基础。由于毒物和社会逆境通常是同时发生的，研究应该考虑这些相互关联的暴露的生命过程后果。
Many gestational exposures influence birth outcomes, yet the joint contribution of toxicant and psychosocial factors is understudied. Moreover, associated gestational epigenetic mechanisms are unknown. Lead (Pb) and depression independently influence birth outcomes and offspring NR3C1 (glucocorticoid receptor) DNA methylation. We hypothesized that gestational Pb and depression would jointly influence birth outcomes and NR3C1 methylation. Pregnancy exposure information, DNA methylation, and birth outcome data were collected prospectively from n = 272 mother–infant pairs. Factor analysis was used to reduce the dimensionality of NR3C1. Multivariable linear regressions tested for interaction effects between gestational Pb and depression exposures with birth outcomes and NR3C1. Interaction effects indicated that higher levels of Pb and depression jointly contributed to earlier gestations, smaller infant size at birth, and asymmetric fetal growth. Pb and depression were also jointly associated with the two primary factor scores explaining the most variability in NR3C1 methylation; NR3C1 scores were associated with some infant outcomes, including gestational age and asymmetric fetal growth. Pb and depression can cumulatively influence birth outcomes and epigenetic mechanisms, which may lay the foundation for later health risk. As toxicants and social adversities commonly co-occur, research should consider the life course consequences of these interconnected exposures.
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影响因子：
3.6
作者：
Baccarelli A;Bollati V
通讯作者：
Bollati V
影响因子：
--
作者：
Grote, Nancy K.;Bridge, Jeffrey A.;Gavin, Amelia R.;Melville, Jennifer L.;Iyengar, Satish;Katon, Wayne J.
通讯作者：
Katon, Wayne J.
影响因子：
3.7
作者：
Conradt, Elisabeth;Lester, Barry M.;Marsit, Carmen J.
通讯作者：
Marsit, Carmen J.
影响因子：
2.3
作者：
Accortt, Eynav Elgavish;Cheadle, Alyssa C. D.;Schetter, Christine Dunkel
通讯作者：
Schetter, Christine Dunkel
影响因子：
9.8
作者：
Elovitz, Michal A.;Anton, Lauren;Brown, Amy G.
通讯作者：
Brown, Amy G.