Referenced scans improve the repeatability of optical coherence tomography angiography measurements in normal and glaucoma eyes.
Referenced scans improve the repeatability of optical coherence tomography angiography measurements in normal and glaucoma eyes.
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DOI：
10.1136/bjophthalmol-2020-316480
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发表时间：
2021-11
影响因子：
4.1
通讯作者：
Weinreb, Robert N.
中科院分区：
文献类型：
--
作者：
Rao, Harsha Laxmana;Dasari, Srilakshmi;Riyazuddin, Mohammed;Lavanya, Raghavan;Narenda, K. P.;Pradhan, Zia Sultan;Moghimi, Sasan;Mansouri, Kaweh;Webers, Carroll A. B.;Weinreb, Robert N.
比较正常眼、疑似青光眼眼和青光眼眼的参考和非参考光学微血管造影（OMAG）扫描的乳头周围灌注密度和流量指数测量的可重复性。在一项横断面研究中，48只眼睛（33名受试者）在同一时间段接受了3次重复的非参考乳头周围OMAG扫描，43只眼睛（25名受试者）接受了3次参考乳头周围OMAG扫描。在参考扫描组中，重复扫描（第二次和第三次扫描）使用器械上的“跟踪到先前扫描”选项在基线（第一次）扫描上精确采集。使用受试者内重复性系数（CRw）和变异系数（CVw）评估非参考和参考扫描的平均和4个扇区（颞、上级、鼻和下）OMAG测量值的重复性估计值。非参考扫描的视乳头周围灌注密度测量值的CRw（%）（范围：2.0至4.1）显著高于参考扫描的CRw（%）（范围：1.4至2.7）。非参考扫描的CVw（%）范围为1.7 - 3.1，参考扫描的CVw（%）范围为1.2 - 2.1。非参考扫描的通量指数CRw范围为4.4 - 5.8，参考扫描为3.6 - 4.8。非参考和参考扫描的CVw范围分别为4.1 - 5.2和3.3 - 4.5。与非参考扫描相比，OMAG测量的重复性估计值在参考扫描上更好。灌注密度测量的变异性低于流量指数。参考扫描的OCTA测量灌注密度对于监测青光眼中的血管变化是优选的。
To compare the repeatability of peripapillary perfusion density and flux index measurements on referenced and non-referenced optical microangiography (OMAG) scans in normal, glaucoma suspect and glaucoma eyes. In a cross-sectional study, 48 eyes (33 subjects) underwent 3 repeat, non-referenced peripapillary OMAG scans in the same session and 43 eyes (25 subjects) underwent 3 referenced peripapillary OMAG scans. In the referenced scan group, repeat scans (second and the third scan) were acquired exactly on the baseline (first) scan using the “track to prior scan” option on the device. Repeatability estimates of the mean and 4-sector (temporal, superior, nasal and inferior) OMAG measurements on the non-referenced and referenced scans were assessed using within-subject coefficient of repeatability (CRw) and variation (CVw). CRw (%) of peripapillary perfusion density measurements (range: 2.0 to 4.1) on non-referenced scans were significantly higher than that on referenced scans (range: 1.4 to 2.7). CVw (%) ranged from 1.7 to 3.1 on non-referenced scans and 1.2 to 2.1 on referenced scans. CRw of flux index on non-referenced scans ranged from 4.4 to 5.8 and on referenced scans from 3.6 to 4.8. CVw on non-referenced and referenced scans ranged from 4.1 to 5.2 and from 3.3 to 4.5 respectively. Repeatability estimates of OMAG measurements were better on referenced compared to non-referenced scans. Perfusion density measurements had lower variability than flux index. OCTA-measured perfusion density of referenced scans are preferable for monitoring vascular change in glaucoma.
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原发性开角型青光眼进行性黄斑血管密度损失：一项纵向研究。
影响因子：
4.2
作者：
Shoji T;Zangwill LM;Akagi T;Saunders LJ;Yarmohammadi A;Manalastas PIC;Penteado RC;Weinreb RN
通讯作者：
Weinreb RN
影响因子：
4.2
作者：
Kwon, Ji Min;Weinreb, Robert N.;Suh, Min Hee
通讯作者：
Suh, Min Hee
影响因子：
4.2
作者：
Rao, Harsha L.;Pradhan, Zia S.;Webers, Carroll A. B.
通讯作者：
Webers, Carroll A. B.
影响因子：
13.7
作者：
Lopilly, Hae-Young;Kim, Jin Woo;Park, Chan Kee
通讯作者：
Park, Chan Kee
影响因子：
2
作者：
Hollo, Gabor
通讯作者：
Hollo, Gabor