Progressive Macula Vessel Density Loss in Primary Open-Angle Glaucoma: A Longitudinal Study.
Progressive Macula Vessel Density Loss in Primary Open-Angle Glaucoma: A Longitudinal Study.
复制标题
原发性开角型青光眼进行性黄斑血管密度损失：一项纵向研究。
DOI：
10.1016/j.ajo.2017.07.011
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发表时间：
2017-10
影响因子：
4.2
通讯作者：
Weinreb RN
中科院分区：
文献类型：
--
作者：
Shoji T;Zangwill LM;Akagi T;Saunders LJ;Yarmohammadi A;Manalastas PIC;Penteado RC;Weinreb RN
描述原发性开角型青光眼（POAG）、可疑青光眼和健康眼的黄斑血管密度损失率。青光眼诊断创新研究的纵向观察队列。纳入100只眼睛（32只POAG，30只青光眼疑似和38只健康），至少随访一年，至少两次访视时进行光学相干断层扫描血管造影（OCT-A）成像。计算黄斑浅层血管密度。使用多变量线性混合效应模型比较诊断组之间的变化率。正常眼黄斑血管密度最高，可疑青光眼和POAG眼次之（P < 0.01）。POAG的血管密度损失率与零有显著差异，但在青光眼可疑眼或健康眼中无显著差异。青光眼眼（-2.23%/年）黄斑全面部血管密度的平均变化率显著快于青光眼可疑眼（0.87%/年，P = 0.001）或健康眼（0.29%/年，P = 0.004）。相反，在任何诊断组中，神经节细胞复合体（GCC）厚度的变化率与零没有显著差异，并且在诊断组之间GCC变化率也没有显著差异，平均随访时间不到14个月，POAG患者的黄斑血管密度明显快于青光眼疑似患者或健康患者。连续OCT-A测量还检测到眼睛中黄斑血管密度的昏迷性变化，而没有GCC厚度变化的证据。
To characterize the rate of macula vessel density loss in primary open angle glaucoma (POAG), glaucoma suspect, and healthy eyes. Longitudinal, observational cohort from the Diagnostic Innovations in Glaucoma Study. One hundred eyes (32 POAG, 30 glaucoma suspect and 38 healthy) followed for at least one year with optical coherence tomography angiography (OCT-A) imaging on at least two visits were included. Vessel density was calculated in the macula superficial layer. The rate of change was compared across diagnostic groups using multivariate linear mixed-effects model. Baseline macula vessel density was highest in healthy eyes, followed by glaucoma-suspect and POAG eyes (P < 0.01). The rate of vessel density loss was significantly different from zero in the POAG, but not in the glaucoma suspect or healthy eyes. The mean rate of change in macula whole en-face vessel density was significantly faster in glaucoma eyes (−2.23 %/yr) than in glaucoma suspect (0.87%/yr, P = 0.001) or healthy eyes (0.29 %/yr, P = 0.004). Conversely, the rate of change in ganglion cell complex (GCC) thickness was not significantly different from zero in any diagnostic group, and no significant differences in the rate of GCC change among diagnostic groups were found. With a mean follow-up of less than 14 months, eyes with POAG had significantly faster loss of macula vessel density than either glaucoma suspect or healthy eyes. Serial OCT-A measurements also detected glaucomatous change in macula vessel density in eyes without evidence of change in GCC thickness.
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影响因子：
13.7
作者：
Jia Y;Wei E;Wang X;Zhang X;Morrison JC;Parikh M;Lombardi LH;Gattey DM;Armour RL;Edmunds B;Kraus MF;Fujimoto JG;Huang D
通讯作者：
Huang D
影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
影响因子：
13.7
作者：
Garas, Anita;Vargha, Peter;Hollo, Gabor
通讯作者：
Hollo, Gabor
DOI：
10.1016/j.ohc.2005.04.001
发表时间：
2005-09-01
期刊：
Ophthalmology clinics of North America
影响因子：
--
作者：
Harris, Alon;Rechtman, Ehud;Garzozi, Hana J
通讯作者：
Garzozi, Hana J
影响因子：
4.2
作者：
Rao, Harsha L.;Pradhan, Zia S.;Webers, Carroll A. B.
通讯作者：
Webers, Carroll A. B.